280 results found
    1. Biochemistry and Chemical Biology

    Nicotinamide mononucleotide adenylyltransferase uses its NAD+ substrate-binding site to chaperone phosphorylated Tau

    Xiaojuan Ma et al.
    Mechanistic insight into the chaperone-like activity of NMNAT to phosphorylated Tau reveals a connection between NAD+metabolism and Tau homeostasis.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Targeting mir128-3p alleviates myocardial insulin resistance and prevents ischemia-induced heart failure

    Andrea Ruiz-Velasco et al.
    Targeting mir128-3p could prevent cardiac insulin resistance in the non-infarcted myocardium and limit cardiac injury after myocardial infarction, delaying the development of heart failure.
    1. Developmental Biology

    Mononuclear diploid cardiomyocytes support neonatal mouse heart regeneration in response to paracrine IGF2 signaling

    Hua Shen et al.
    Neonatal mouse heart regeneration relies on the presence of mononuclear diploid cardiomyocytes, which unites this process with embryonic heart growth and adult heart regeneration.
    1. Cancer Biology
    2. Cell Biology

    Drosophila TRIM32 cooperates with glycolytic enzymes to promote cell growth

    Simranjot Bawa et al.
    TRIM32-mediated glycolytic flux generates precursors that are utilized for biomass production in non-dividing muscle, brain and tumor cells, demonstrating a universal metabolic function for TRIM32 in cell growth.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Global genome diversity of the Leishmania donovani complex

    Susanne U Franssen et al.
    Genomic data for the parasites that cause visceral leishmaniasis provides the first global picture of the diversity and evolution of the pathogen and the epidemiology of this fatal tropical disease.
    1. Cell Biology

    A highly responsive pyruvate sensor reveals pathway-regulatory role of the mitochondrial pyruvate carrier MPC

    Robinson Arce-Molina et al.
    A user-friendly genetically-encoded fluorescent sensor of improved dynamic range is introduced to facilitate the study of mitochondrial metabolism and diversity.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Chemoptogenetic ablation of neuronal mitochondria in vivo with spatiotemporal precision and controllable severity

    Wenting Xie et al.
    Novel transgenic zebrafish lines allow selective ablation of neuronal mitochondria by far red light, providing a powerful tool for investigating mitochondrial homeostasis in neurons and mitochondrial mechanisms in neurological disease.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Homologue replacement in the import motor of the mitochondrial inner membrane of trypanosomes

    Corinne von Känel et al.
    Mitochondrial inner membrane translocation of presequence-containing proteins by the single bifunctional TIM complex of T. brucei requires an non-canonical J domain-containing protein.
    1. Immunology and Inflammation

    A novel role for lipoxin A4 in driving a lymph node–eye axis that controls autoimmunity to the neuroretina

    Jessica Wei et al.
    LXA4 in lymph nodes is an important resident homeostatic regulator that controls effector T cell functions and egress in the development of adaptive immune responses.
    1. Immunology and Inflammation

    Thioredoxin-1 distinctly promotes NF-κB target DNA binding and NLRP3 inflammasome activation independently of Txnip

    Jonathan Muri et al.
    The thioredoxin-1 (Trx1) system promotes inflammation by positively regulating both NLRP3 inflammasome responses, by detoxifying excessive ROS independently of Txnip and NF-κB binding to target DNA.

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