187 results found
    1. Computational and Systems Biology
    2. Developmental Biology and Stem Cells

    A multi-scale model for hair follicles reveals heterogeneous domains driving rapid spatiotemporal hair growth patterning

    Qixuan Wang et al.
    Regional differences in activator and inhibitor signals alter hair cycle pace across mouse skin and produce unique fur renewal 'landscapes', with fastest renewal on the ventrum and slowest renewal on the ear pinnae.
    1. Developmental Biology and Stem Cells

    Loss of Ptpn11 (Shp2) drives satellite cells into quiescence

    Joscha Griger et al.
    The stem cells of the postnatal muscle allow postnatal muscle growth and repair and withdraw from the cell cycle when the tyrosine phosphatase Ptpn11 (Shp2) is inhibited or mutated in mice.
    1. Neuroscience

    Two-photon calcium imaging of the medial prefrontal cortex and hippocampus without cortical invasion

    Masashi Kondo et al.
    Establishment of two-photon imaging with a 1100-nm laser, which underfills the objective's back aperture, detects activity of multiple neurons in the prelimbic area and hippocampal CA1 region of the intact mouse brain.
    1. Neuroscience

    Defective synaptic transmission causes disease signs in a mouse model of juvenile neuronal ceroid lipofuscinosis

    Benedikt Grünewald et al.
    Impaired GABAergic and glutamatergic synaptic function and loss of interneurons in the amygdala, hippocampus, and cerebellum cause characteristic disease symptoms in a mouse model juvenile neuronal ceroid lipofuscinosis.
    1. Cancer Biology
    2. Cell Biology

    Negative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells

    Michiel van Veen et al.
    GDE3 is a transmembrane GPI-specific phospholipase C that sheds the urokinase receptor (uPAR) from the cell surface resulting in loss of uPAR function in breast cancer cells and reduced tumor growth.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure

    Taesun Eom et al.
    The HITS-CLIP sequencing method is used to demonstrate that cryptic exons can detect messenger RNA that contains nonsense mutations, and then cause this RNA to decay, which shows that these exons are involved in maintaining the electrical balance of neurons and, possibly, preventing epilepsy.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    Differential TAM receptor–ligand–phospholipid interactions delimit differential TAM bioactivities

    Erin D Lew et al.
    Signaling by TAM receptor tyrosine kinases requires the coincident engagement of a TAM ligand with both its receptor and the phospholipid phosphatidylserine.
    1. Computational and Systems Biology
    2. Developmental Biology and Stem Cells

    Dynamics of BMP signaling and distribution during zebrafish dorsal-ventral patterning

    Autumn P Pomreinke et al.
    Patterning of the dorsal-ventral axis in zebrafish is mediated by a graded source-sink mechanism in which diffusing BMP, produced from a ventrally biased source, is inhibited by dorsally-produced chordin.
    1. Neuroscience

    Fast two-photon imaging of subcellular voltage dynamics in neuronal tissue with genetically encoded indicators

    Simon Chamberland et al.
    The combination of a new genetically encoded voltage indicator and fast two-photon imaging methods enables detection of rapid neural electrical activity in organotypic slice cultures and in living flies.
    1. Developmental Biology and Stem Cells
    2. Neuroscience

    Zeb1 controls neuron differentiation and germinal zone exit by a mesenchymal-epithelial-like transition

    Shalini Singh et al.
    Neuronal progenitor cells autonomously inhibit polarization via the transcription factor Zeb1.

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