298 results found
    1. Computational and Systems Biology
    2. Developmental Biology

    Modularity, criticality, and evolvability of a developmental gene regulatory network

    Berta Verd et al.
    A new approach focusing on dynamic modularity helps overcome traditional challenges detecting modularity in complex adaptive systems.
    1. Evolutionary Biology

    Fitness variation across subtle environmental perturbations reveals local modularity and global pleiotropy of adaptation

    Grant Kinsler et al.
    A set of adaptive mutations affect only a small number of phenotypes that matter in the evolution condition, and yet contain substantial latent functional diversity revealed in distant environments.
  1. Meta-Research: Tracking the popularity and outcomes of all bioRxiv preprints

    Richard J Abdill, Ran Blekhman
    Data are reported for the monthly number of uploads to and downloads from bioRxiv, and for the number of preprints that are later published in peer-reviewed journals.
    1. Developmental Biology
    2. Neuroscience

    Establishment and maintenance of motor neuron identity via temporal modularity in terminal selector function

    Yinan Li et al.
    The terminal selector-type transcription factor UNC-3/Ebf partially modifies the suite of its target genes at different life stages to establish and maintain the identity of C. elegans motor neurons.
    1. Biochemistry and Chemical Biology

    A toolkit for studying cell surface shedding of diverse transmembrane receptors

    Amanda N Hayward et al.
    The modularity and unequivocal input/response of Notch signaling are harnessed to measure cell-surface shedding of diverse transmembrane receptors to identify new proteolytic switches and detect modulation of proteolysis by therapeutics.
    1. Neuroscience

    Self-organization of modular network architecture by activity-dependent neuronal migration and outgrowth

    Samora Okujeni, Ulrich Egert
    Activity-dependent neurite outgrowth and neuronal migration interact to shape modular mesoscale network architecture by homeostatic self-organization.
    1. Neuroscience

    Inter- and intra-animal variation in the integrative properties of stellate cells in the medial entorhinal cortex

    Hugh Pastoll et al.
    Setpoints that determine the integrative properties of neurons in the medial entorhinal cortex are established at a population level and differ between animals.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Modularity and determinants of a (bi-)polarization control system from free-living and obligate intracellular bacteria

    Matthieu Bergé et al.
    Common ancestries, activities and structural determinants of a modular (bi-)polarization control system encoded in free-living and obligate intracellular α-proteobacteria, including the rickettsial pathogens, are described.
    1. Neuroscience
    2. Physics of Living Systems

    A geometric attractor mechanism for self-organization of entorhinal grid modules

    Louis Kang, Vijay Balasubramanian
    The hierarchy of entorhinal grid cell modules with constant scale ratios can self-organize through a new geometrically organized attractor mechanism.
    1. Evolutionary Biology

    Novel neuroanatomical integration and scaling define avian brain shape evolution and development

    Akinobu Watanabe et al.
    More integrated brains in crown birds evolved through a mosaic assembly of new evolutionary and developmental dynamics across neuroanatomical regions that occurred along the dinosaur-bird transition.

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