Hematopoietic stem and progenitor cells are heterogeneous on a population level, while cells derived from a common ancestor have similar division and differentiation patterns, indicating priming towards a certain differentiation/division fate.
An anatomically constrained computational model of the macaque cortical network demonstrates the emergence of large-scale distributed patterns of mnemonic activity sustained by long-range cortico-cortical interactions.
Sebastian Bohm, Falk Mersmann ... Adamantios Arampatzis
During human running, the soleus muscle was found to operate as work generator under optimal conditions for work production (high force-length potential and enthalpy efficiency) while the vastus lateralis promoted tendon energy storage and economical force generation (high force-length-velocity potential).
Atomu Yamaguchi, Noriaki Maeshige ... Hidemi Fujino
Ultrasound promotes release of extracellular vesicles from cultured myotubes and elicits anti-inflammatory effects on macrophages, indicating the potential of ultrasound stimulation to muscle for anti-inflammatory purposes.
The location of impact sounds, common stimuli whose detection is crucial for survival, is encoded by a precise interaction between excitation and inhibition rather than coincidence detection of excitatory events.
Inhibiting RNA N6-methyladenosine demethylase ALKBH5 promoted axonal regeneration of dorsal root ganglion neurons by regulating stability of Lpin2 mRNA and enhanced the survival and axonal regeneration of retinal ganglion cells.
Analysis of mice lacking the precursor for irisin, FNDC5, provides evidence for a sex-specific role of irisin in calcium release from bone due to osteocytic osteolysis.
