260 results found
    1. Computational and Systems Biology
    2. Genetics and Genomics

    RNA splicing programs define tissue compartments and cell types at single-cell resolution

    Julia Eve Olivieri, Roozbeh Dehghannasiri ... Julia Salzman
    Comprehensive analysis of alternative splicing from human droplet-based scRNA-seq data identifies genes with regulated splicing conserved in mouse and mouse lemur.
    1. Evolutionary Biology
    2. Neuroscience

    Mice and primates use distinct strategies for visual segmentation

    Francisco J Luongo, Lu Liu ... Doris Y Tsao
    The behavioral ability of mice and treeshrews to detect visual figures is highly texture dependent, unlike that of primates including macaques and mouse lemurs, and neural responses to figures in mouse visual cortex are similarly texture dependent.
    1. Genetics and Genomics

    Epigenetic profiling of growth plate chondrocytes sheds insight into regulatory genetic variation influencing height

    Michael Guo, Zun Liu ... Terence D Capellini
    Epigenetic profiling of femoral growth plate chondrocytes helps whittle-down GWAS height variants to fewer putative functional variants.
    1. Evolutionary Biology

    Evolutionary stasis of the pseudoautosomal boundary in strepsirrhine primates

    Rylan Shearn, Alison E Wright ... Gabriel AB Marais
    A larger non-recombining region in sexually dimorphic primates compared to sexually monomorphic ones supports the view that sexually antagonistic mutations have influenced the evolution of sex chromosomes in primates.
    1. Genetics and Genomics
    2. Medicine

    Differences in pathways contributing to thyroid hormone effects on postnatal cartilage calcification versus secondary ossification center development

    Gustavo A Gomez, Patrick Aghajanian ... Subburaman Mohan
    Mouse molecular genetics and in vivo functional studies reveal that thyroid hormone is necessary for punctual proximal femur head development by a mechanism that differs temporally and molecularly from the secondary ossification center at the distal femur.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Siglec receptors impact mammalian lifespan by modulating oxidative stress

    Flavio Schwarz, Oliver MT Pearce ... Pascal Gagneux
    By contributing to the maintenance of ROS homeostasis, CD33-related Siglecs control oxidative damage and influence rate of aging and lifespan.
    1. Cell Biology
    2. Genetics and Genomics

    A trans-eQTL network regulates osteoclast multinucleation and bone mass

    Marie Pereira, Jeong-Hun Ko ... Jacques Behmoaras
    MMnet is a conserved, trans-regulated gene network that controls skeletal homeostasis through osteoclast multinucleation and bone resorptive function.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Independent amylase gene copy number bursts correlate with dietary preferences in mammals

    Petar Pajic, Pavlos Pavlidis ... Omer Gokcumen
    Comprehensive analyses of amylase duplications and salivary activity across mammals underscore the importance of recurrent copy number variation as a flexible and rapid evolutionary mechanism.
    1. Epidemiology and Global Health
    2. Medicine

    Evaluating mesenchymal stem cell therapy for sepsis with preclinical meta-analyses prior to initiating a first-in-human trial

    Manoj M Lalu, Katrina J Sullivan ... Lauralyn McIntyre
    A rigorous and transparent evaluation of mesenchymal stem cell therapy for sepsis suggests it may be efficacious, although the strength of these findings is tempered by threats to validity in the studies that were included.
    1. Developmental Biology

    Clec11a/osteolectin is an osteogenic growth factor that promotes the maintenance of the adult skeleton

    Rui Yue, Bo Shen, Sean J Morrison
    A C-type lectin domain protein is an anabolic growth factor that promotes mesenchymal progenitors in the bone marrow to differentiate into bone cells to maintain skeletal bone mass throughout adult life.

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