A mechanistic link between TLE3 loss and glucocorticoid receptor-mediated androgen receptor inhibitor resistance supports the rationale to target GR during anti-hormonal treatment in castrate-resistant prostate cancer.

The GTPase Nog1 orchestrates stalk assembly, peptidyl transferase centre maturation and polypeptide exit tunnel quality control.

The specification of a very small number of progenitor cells with competence to adapt their neurogenic output to different probabilistic rules underlies the generation of distinct cortical cytoarchitectures.

Genes implicated in mutant mRNA decay and small RNA maturation and transport into the nucleus are required for transcriptional adaptation in C. elegans.

The wide range of cell types produced by single progenitors in the neocortex of mice may result from stochastic rather than deterministic processes.

The rat is much more than a simple model, and a better appreciation of the natural history of wild rats would increase its value as a research organism.

The Timothy syndrome mutation in Ca_v1.2 gives rise to defects in neuronal differentiation by preventing a developmental switch in channel splicing and elevating calcium signaling in differentiating cells.