Profilin helps to maintain formin at the growing barbed end of an actin filament, while piconewton mechanical tension drastically enhances formin dissociation from the barbed end.

Synthetic single domain antibody libraries and a binder selection cascade encompassing ribosome and phage display enable the selection of conformation-specific binders against previously intractable membrane proteins within three weeks.

Within distinct chromatin landscapes, the BRG1 chromatin remodeling enzyme patterns hormone-dependent chromatin interactions, pioneer factor recruitment, and transcriptional activity.

The IFNλ family of interferons controls the spread of viruses in the upper respiratory tract and transmission between mice.

Autistic traits are associated with weaker influence of prior expectations in visual perception, which is due to more precise sensory representations.

RNA-binding protein SRSF3 mediates critical changes in RNA processing of pluripotency genes, which reveals functional consequences of regulated RNA processing during stem cell self-renewal and early development.

Binding of multiple LC8 copies to the intrinsically disordered region of the transcription factor ASCIZ exemplifies a new and potentially widespread molecular mechanism for negative feedback regulation.

A derived stress response trait may have contributed to the emergence of a globally dominant and promiscuous parasite.

Transgenic expression of glucanase, xylanase and phytase in pigs enhances growth performance and reduces nitrogen/phosphorus emission, and offers a very valuable biological strategy for sustainable resource utilization and environmental protection in the pork industry.

A biallelic missense mutation in the highly conserved, neuron-specific kinase CAMK2A abrogates holoenzyme assembly and causes a new inherited neurodevelopmental disease.