A new methodology and protocol use automated brain imaging and task training technology to probe links between behavior and mouse cortical circuits.

The splicing factor RNP-6/PUF60 suppresses immunity by modulating host splicing and transcriptional responses to infection.

In stau^-mutants, the Hunchback boundary shifts posteriorly by 10% EL but shows comparable variability to that of the wild type in short time windows in nuclear cycle 14.

An adenylyl cyclase isoform is shown to dynamically traffic to endosomes after activation by G protein in mammalian cells, contributing to cellular cAMP signaling by internalized GPCRs.

Interaction mapping of ubiquitin ligase complexes embedded in the endoplasmic reticulum membrane has identified interactors of RNF26 that influence innate immune signalling.

The global sleep homeostatic process tracks sleep-wake history by integrating local cortical neuronal activity over time and space, rather than directly reflecting changes in specific homeostatically regulated physiological variables.

Optogenetic activation of cortical GABAergic cells in macaques yields robust and reversible behavioral deficits.