291 results found
    1. Cell Biology

    Protein Phosphatase 1 inactivates Mps1 to ensure efficient Spindle Assembly Checkpoint silencing

    Margarida Moura et al.
    Inactivation of the master mitotic checkpoint regulator Mps1 by protein phosphatase 1 is required for timely segregation of the genetic material during cell division.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Pathogenic PS1 phosphorylation at Ser367

    Masato Maesako et al.
    PS1 phosphorylation at Ser367 is the potential hyperactivity-driven culprit of pathogenic change in PS1 conformation in vitro and in vivo.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A sequential multi-target Mps1 phosphorylation cascade promotes spindle checkpoint signaling

    Zhejian Ji et al.
    The spindle checkpoint kinase Mps1 sequentially phosphorylates multiple substrates to amplify checkpoint signals, making the checkpoint highly dependent on Mps1 function and directly responsive to kinetochore-microtubule attachment.
    1. Cell Biology

    The AAA protein Msp1 mediates clearance of excess tail-anchored proteins from the peroxisomal membrane

    Nicholas R Weir et al.
    Msp1, a membrane-integral AAA ATPase at mitochondria and peroxisomes, selectively recognizes uncomplexed substrate molecules in vivo while avoiding substrates stabilized by binding partners.
    1. Cell Biology

    Cooperation of mitochondrial and ER factors in quality control of tail-anchored proteins

    Verena Dederer et al.
    The endoplasmic reticulum E3 ubiquitin ligase Doa10 and the mitochondrial AAA-ATPase Msp1 govern targeting fidelity of outer mitochondrial tail-anchored proteins by controlling cytoplasmic concentration and extracting mistargeted and orphan species.
    1. Human Biology and Medicine
    2. Immunology and Inflammation

    Response to comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'

    Christina Hertel et al.
    We are writing to reply to the comment by Landegren et al., 2019 about our study (Meyer et al., 2016) on disease-ameliorating autoantibodies.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Cell Cycle: Micromanaging checkpoint proteins

    Andrea Ciliberto, Silke Hauf
    The kinase Mps1, long known to be the 'boss' in mitotic checkpoint signaling, phosphorylates multiple proteins in the checkpoint signaling cascade.
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    1. Cell Biology
    2. Chromosomes and Gene Expression

    The human SKA complex drives the metaphase-anaphase cell cycle transition by recruiting protein phosphatase 1 to kinetochores

    Sushama Sivakumar et al.
    Microtubule binding by the Spindle and Kinetochore Associated (Ska) complex concentrates protein phosphatase 1 at metaphase kinetochores to overcome the spindle checkpoint thus driving anaphase onset and mitotic exit.
    1. Human Biology and Medicine
    2. Immunology and Inflammation

    Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'

    Nils Landegren et al.
    We are writing to comment on the study by Meyer et al., 2016 on disease-ameliorating autoantibodies.

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