M Regina Scarpin, Samuel Leiboff, Jacob O Brunkard
Plants and humans use a shared mechanism, the eukaryotic metabolic sensor TARGET OF RAPAMYCIN protein kinase and its substrate, an RNA-binding protein called LARP1, to coordinate post-transcriptional gene expression.
A human experimental model for physiological glucocorticoid exposure and glucocorticoid withdrawal identifies a multi-omic cluster, including microRNA miR-122-5p and metabolites, associated with glucocorticoid-responsive genes.
Selective degradation of mature miRNAs shapes temporal miRNA expression patterns and is important for proper regulation of target genes to support normal development of Drosophila embryos.
Complementing experimental data from EPR spectroscopy with computational modeling techniques provides access to protein structural dynamics and enables the characterization of rare protein conformations.
Marina Diskowski, Ahmad Reza Mehdipour ... Inga Hänelt
The K(+) uptake system KtrAB is controlled by an allosteric mechanism entirely new for membrane channels, which operates the channel gate over a 35 Å distance.
Sven Dennerlein, Sabine Poerschke ... Peter Rehling
Definition of the mitoribosome interactome revealed inner membrane proteins and elucidated new assembly factors of the cytochrome c reductase and cytochrome c oxidase.
Harleen Saini, Alicia A Bicknell ... Melissa J Moore
A systematic study of RNA localization unexpectedly finds a set of free circular introns with a non-canonical C branchpoint enriched in neuronal projections.
