152 results found
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Combining genomics and epidemiology to analyse bi-directional transmission of Mycobacterium bovis in a multi-host system

    Joseph Crispell et al.
    Analyses combining genomic and epidemiological data of Mycobacterium bovis, which causes bovine tuberculosis, revealed evidence of transmission within and between cattle and badger populations.
    1. Microbiology and Infectious Disease

    Flexible nitrogen utilisation by the metabolic generalist pathogen Mycobacterium tuberculosis

    Aleksandra Agapova et al.
    Metabolomics and stable isotope labelling studies of virulent Mycobacterium tuberculosis reveal a de-centralised metabolic network able to utilise various amino acids as nitrogen sources to a better extent than ammonium.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Essential yet limited role for CCR2+ inflammatory monocytes during Mycobacterium tuberculosis-specific T cell priming

    Miriam Samstein et al.
    Inflammatory monocytes carry live Mycobacteria from the lung to draining lymph nodes and acquire many characteristics of dendritic cells but fail to stimulate proliferation of CD4 T cells.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Peptidoglycan precursor synthesis along the sidewall of pole-growing mycobacteria

    Alam García-Heredia et al.
    Peptidoglycan precursor synthesis occurs in both growing and non-growing regions of the mycobacterial cell surface.
    1. Microbiology and Infectious Disease

    Maturing Mycobacterium smegmatis peptidoglycan requires non-canonical crosslinks to maintain shape

    Catherine Baranowski et al.
    Polar elongating mycobacteria (Mycobacterium smegmatis) require specific cell wall chemistries, those catalyzed by targets of critical antibiotics, to maintain rod shape at aging sites of the bacillus.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A cytoplasmic peptidoglycan amidase homologue controls mycobacterial cell wall synthesis

    Cara C Boutte et al.
    Cell wall biosynthesis in mycobacteria is regulated by an unusual post-translational regulatory system that contributes to antibiotic tolerance during stress.
    1. Immunology and Inflammation

    Mycolic acid-specific T cells protect against Mycobacterium tuberculosis infection in a humanized transgenic mouse model

    Jie Zhao et al.
    A humanized transgenic mouse model reveals that CD1b-restricted, mycolic acid-specific T cells play a protective role during Mycobacterium tuberculosis infection.
    1. Microbiology and Infectious Disease

    Rv3723/LucA coordinates fatty acid and cholesterol uptake in Mycobacterium tuberculosis

    Evgeniya V Nazarova et al.
    The integral membrane protein LucA facilitates fatty acid and cholesterol uptake into Mycobacterium tuberculosis by stabilizing the Mce1 and Mce4 transporters, respectively, and Mce1 functions as a fatty acid transporter in Mycobacterium tuberculosis.
    1. Structural Biology and Molecular Biophysics

    Fidaxomicin jams Mycobacterium tuberculosis RNA polymerase motions needed for initiation via RbpA contacts

    Hande Boyaci et al.
    Cryo-electron microscopy structures show how the clinically used antimicrobial fidaxomicin binds and inhibits Mycobacterium tuberculosis RNA polymerase by acting like a doorstop to jam the enzyme in an open conformation via the general transcription factor RbpA.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Identification of scavenger receptor B1 as the airway microfold cell receptor for Mycobacterium tuberculosis

    Haaris S Khan et al.
    Mycobacterium tuberculosis penetrates the airway mucosa through M cells via the mycobacterial virulence factor EsxA and the host M cell surface receptor scavenger receptor B1.

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