25 results found
    1. Physics of Living Systems

    Downsizing the molecular spring of the giant protein titin reveals that skeletal muscle titin determines passive stiffness and drives longitudinal hypertrophy

    Ambjorn Brynnel et al.
    Genetically altering the size of the molecular spring element in the giant protein titin established that titin determines the stiffness of skeletal muscle and the number of sarcomeres in series.
    1. Structural Biology and Molecular Biophysics

    Myosin motors fragment and compact membrane-bound actin filaments

    Sven K Vogel et al.
    A combination of single-molecule imaging and an in vitro model of the cell cortex has allowed the interactions between actin filaments and filaments made of myosin II to be studied in detail.
    1. Ecology

    Ant colonies maintain social homeostasis in the face of decreased density

    Andreas P Modlmeier et al.
    Organizational resilience allows ant colonies to retain high interaction rates in the face of decreased density by altering their spatial and social dynamics.
    1. Cell Biology
    2. Ecology

    Ubiquitous macropinocytosis in anthozoans

    Philippe Ganot et al.
    Macropinocytosis, the process of non-specific endocytosis, is a major gateway for large volumes of surrounding medium and nanoparticles to coral cells.
    1. Evolutionary Biology
    2. Neuroscience

    Physiological constraint on acrobatic courtship behavior underlies rapid sympatric speciation in bearded manakins

    Meredith C Miles et al.
    Skeletal muscle performance sets the course of rapid speciation by defining the evolutionary trajectory of reproductive behavior.
    1. Cell Biology

    The step-wise pathway of septin hetero-octamer assembly in budding yeast

    Andrew Weems, Michael McMurray
    In budding yeast cells, slow monomeric septin GTPase activity and the cytosolic GTP:GDP ratio dictate the relative incorporation of alternative subunits during septin hetero-oligomer assembly, which proceeds by discrete, ordered steps dependent on allostery between interaction interfaces.
    1. Developmental Biology

    Calcium handling precedes cardiac differentiation to initiate the first heartbeat

    Richard CV Tyser et al.
    High-resolution live imaging reveals how and when the mouse heart first starts to beat during development and how the onset of beating impacts on heart muscle cell maturation and heart formation.
    1. Human Biology and Medicine
    2. Neuroscience

    Spinal signalling of C-fiber mediated pleasant touch in humans

    Andrew G Marshall et al.
    Pleasant touch perception in humans is unaffected by spinothalamic disruption indicating integrated spinal processing of hedonic and discriminative tactile inputs rather than privileged C-tactile-lamina I-spinothalamic projections.
    1. Cell Biology

    The DWORF micropeptide enhances contractility and prevents heart failure in a mouse model of dilated cardiomyopathy

    Catherine A Makarewich et al.
    Cardiac-specific overexpression of a recently discovered micropeptide, DWORF, enhances calcium cycling and contractility in the heart and rescues the heart failure phenotype of a genetic mouse model of dilated cardiomyopathy.
    1. Ecology
    2. Neuroscience

    Select forelimb muscles have evolved superfast contractile speed to support acrobatic social displays

    Matthew J Fuxjager et al.
    In situ measurements of muscular twitch speed reveal one of the fastest vertebrate limb muscles on record, which evolved in association with extravagant courtship displays that include rapid limb movements.

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