848 results found
    1. Neuroscience

    Myosin V functions as a vesicle tether at the plasma membrane to control neurotransmitter release in central synapses

    Dario Maschi et al.
    Synaptic vesicles undergo reversible tethering at the plasma membrane which is activity- and myosin V- dependent.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Myosin III-mediated cross-linking and stimulation of actin bundling activity of Espin

    Haiyang Liu et al.
    The tail domain of Myosin III binds to and cross-links actin bundling protein Espin1 and thus modulates higher order actin bundle structures in cellular processes such as stereocilia and microvilli.
    1. Structural Biology and Molecular Biophysics

    Structural dynamics of myosin 5 during processive motion revealed by interferometric scattering microscopy

    Joanna Andrecka et al.
    Single molecule imaging reveals how the molecular motor myosin 5 walks in a compass-like spinning motion along its actin track resulting in efficient, robust and unidirectional motion on the nanoscale.
    1. Structural Biology and Molecular Biophysics

    Myosin motors fragment and compact membrane-bound actin filaments

    Sven K Vogel et al.
    A combination of single-molecule imaging and an in vitro model of the cell cortex has allowed the interactions between actin filaments and filaments made of myosin II to be studied in detail.
    1. Structural Biology and Molecular Biophysics

    Mechanistic insights into the active site and allosteric communication pathways in human nonmuscle myosin-2C

    Krishna Chinthalapudi et al.
    R788 is part of an allosteric communication pathway that connects the converter at the distal end of the myosin motor domain via the relay helix with switch-2 of the active site.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Coordinated recruitment of Spir actin nucleators and myosin V motors to Rab11 vesicle membranes

    Olena Pylypenko et al.
    Components of a Spir:MyoV:Rab11 complex are recruited synergistically to coordinate actin tracks generation and myosin motor activity in vesicle transport processes.
    1. Neuroscience

    A large fraction of neocortical myelin ensheathes axons of local inhibitory neurons

    Kristina D Micheva et al.
    Parvalbumin-positive inhibitory neurons in the cortex have insulating myelin sheathes, despite forming only short-range connections.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Small molecule-mediated refolding and activation of myosin motor function

    Michael B Radke et al.
    The small molecule EMD 57033 is one of a new class of pharmacological chaperones that stabilize, enhance the activity of, and correct stress-induced misfolding of myosin proteins.
    1. Neuroscience

    Anillin facilitates septin assembly to prevent pathological outfoldings of central nervous system myelin

    Michelle S Erwig et al.
    Mature myelin sheaths are scaffolded by the anillin-dependent assembly of septin filaments, thereby facilitating rapid nerve conduction in the healthy CNS.
    1. Structural Biology and Molecular Biophysics

    Structure analyses reveal a regulated oligomerization mechanism of the PlexinD1/GIPC/myosin VI complex

    Guijun Shang et al.
    PlexinD1 binding releases GIPC autoinhibition, leading to formation of high-order oligomers of the GIPC/myosin VI complex.

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