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    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Small molecule-mediated refolding and activation of myosin motor function

    Michael B Radke et al.
    The small molecule EMD 57033 is one of a new class of pharmacological chaperones that stabilize, enhance the activity of, and correct stress-induced misfolding of myosin proteins.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Bipolar filaments of human nonmuscle myosin 2-A and 2-B have distinct motile and mechanical properties

    Luca Melli et al.
    Individual nonmuscle myosin 2 filaments in cells may differ their mechanical and kinetic properties depending on the myosin paralog composition giving the cells a mechanism for fine tuning the output of a given nonmuscle myosin filament.
    1. Cell Biology
    2. Human Biology and Medicine

    Prolonged cross-bridge binding triggers muscle dysfunction in a Drosophila model of myosin-based hypertrophic cardiomyopathy

    William A Kronert et al.
    Integrative analysis of a Drosophila model of hypertrophic cardiomyopathy demonstrates that prolonged binding of the myosin cross-bridge to actin is a root cause of the disorder.
    1. Physics of Living Systems

    Increasing evidence of mechanical force as a functional regulator in smooth muscle myosin light chain kinase

    Fabian Baumann et al.
    Atomic force microscopy based single-molecule force spectroscopy of smooth muscle myosin light chain kinase strongly indicates the existence of a mechanically triggerable activation pathway analogous to its well-established biochemical regulation pathway via calcium-loaded calmodulin.
    1. Cell Biology
    2. Physics of Living Systems

    Myosin II isoforms play distinct roles in adherens junction biogenesis

    Mélina L Heuzé et al.
    Myosin isoforms exhibit different functions in the formation of adherens junctions and the transmission of mechanical forces.
    1. Cell Biology

    Type-I myosins promote actin polymerization to drive membrane bending in endocytosis

    Hetty E Manenschijn et al.
    Monomeric myosins can stimulate growth of actin filaments under load.
    1. Structural Biology and Molecular Biophysics

    Structure analyses reveal a regulated oligomerization mechanism of the PlexinD1/GIPC/myosin VI complex

    Guijun Shang et al.
    PlexinD1 binding releases GIPC autoinhibition, leading to formation of high-order oligomers of the GIPC/myosin VI complex.
    1. Neuroscience

    Proteome profile of peripheral myelin in healthy mice and in a neuropathy model

    Sophie B Siems et al.
    A comprehensive compendium of myelin proteins in the peripheral nervous system has been created, alongside a method to address molecular diversity of myelin sheaths in health and disease.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Myosin V executes steps of variable length via structurally constrained diffusion

    David Hathcock et al.
    A theoretical model comprehensively describes the stepping dynamics of the motor protein myosin V, unraveling the significance of a recently discovered structural constraint on the angle between its lever arms.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structures reveal specialization at the myosin VI-actin interface and a mechanism of force sensitivity

    Pinar S Gurel et al.
    Cryo-EM structures of actomyosin VI in multiple nucleotide states reveal a unique actin-myosin interface and a mechanism of force-sensitivity; furthermore, myosin VI remodels F-actin, suggesting a role for actin structural plasticity during force generation.