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    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Functional genomics of lipid metabolism in the oleaginous yeast Rhodosporidium toruloides

    Samuel T Coradetti et al.
    Using barcoded mutagenesis and a high-throughput genetic screen results in the identification of 150 genes that affect lipid accumulation in a non-model yeast system.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Visualizing the functional architecture of the endocytic machinery

    Andrea Picco et al.
    A combination of light and electron microscopy data provide new insights into the dynamic architecture and the function of the endocytic protein machinery in relation to membrane shape changes in vivo.
    1. Cell Biology
    2. Neuroscience

    Synaptotagmin 7 functions as a Ca2+-sensor for synaptic vesicle replenishment

    Huisheng Liu et al.
    Two proteins—synaptotagmin 7 and calmodulin—have central roles in the calcium-dependent pathway that maintains synaptic transmission.
    1. Neuroscience

    Monkey EEG links neuronal color and motion information across species and scales

    Florian Sandhaeger et al.
    Using Monkey EEG as a bridge technology, color and motion representations in human MEG are linked to microcircuit activity in ventral stream areas.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    A tRNA modification balances carbon and nitrogen metabolism by regulating phosphate homeostasis

    Ritu Gupta et al.
    The role of an amino acid-dependent tRNA modification as a nutrient sensor and regulator of metabolic homeostasis has been discovered.
    1. Cancer Biology
    2. Human Biology and Medicine

    Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases

    Paul A Clarke et al.
    Detailed molecular profiling investigations alongside antitumor testing and tolerability studies in animals suggest caution when considering the clinical development of inhibitors of CDK8 and CDK19, since a clear therapeutic window could not be demonstrated with two structurally distinct, potent and selective prototype drugs.
    1. Microbiology and Infectious Disease

    Streptomyces exploration is triggered by fungal interactions and volatile signals

    Stephanie E Jones et al.
    Exploratory growth is a newly discovered mode of Streptomyces growth that it is stimulated by fungi, is pH responsive, and can be communicated to other – physically separated – streptomycetes through airborne compounds.
    1. Chromosomes and Gene Expression

    Rapid epigenetic adaptation to uncontrolled heterochromatin spreading

    Jiyong Wang et al.
    Redundant pathways prevent heterochromatin spreading and ectopic heterochromatin assembly; and plasticity of heterochromatin assembly allows cells to adapt to heterochromatin stress.
    1. Genetics and Genomics

    Rare variants contribute disproportionately to quantitative trait variation in yeast

    Joshua S Bloom et al.
    Rare, evolutionarily recent variants have larger effect sizes and are more likely to decrease fitness, providing evidence that quantitative traits in yeast have evolved under purifying selection.
    1. Cancer Biology

    Regulation of the glucocorticoid receptor via a BET-dependent enhancer drives antiandrogen resistance in prostate cancer

    Neel Shah et al.
    Epigenetic regulation of the glucocorticoid receptor in castration-resistant prostate cancer can be targeted via the use of BET bromodomain inhibitors.