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    1. Cell Biology
    2. Developmental Biology

    Matrix metalloproteinase 14 is required for fibrous tissue expansion

    Susan H Taylor et al.
    The membrane type I-matrix metalloproteinase is essential for the release of collagen fibrils from plasma membrane fibripositors, which is required for the transition from embryonic to postnatal tendon development.
  1. Living Science: Grandmother elephants

    Eve Marder
    As new technology makes it possible to perform experiments that were unimaginable a decade ago, Eve Marder argues that we can still learn from the past.
  2. Plain-language Summaries of Research: The value of a healthy relationship

    Bridget M Kuehn
    Biomedical science benefits when plain language allows patients to engage with all stages of the research process.
  3. Point of View: A fair deal for PhD students and postdocs

    Henry R Bourne
    The relentless expansion that threatens the sustainability of biomedical research in the US takes a heavy toll on young researchers.
    1. Biochemistry and Chemical Biology

    Point of View: How open science helps researchers succeed

    Erin C McKiernan et al.
    Open research practices bring significant benefits to researchers.
    1. Cancer Biology

    Reproducibility Project: Cancer Biology: Time to do something about reproducibility

    Sean J Morrison
    Individual scientists, scientific communities and scientific journals can do more to assess the publication of irreproducible results, to promote good science, and to increase the efficiency with which the scientific community self-corrects.
    Editorial
    Available as:
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    1. Neuroscience

    Myosin V functions as a vesicle tether at the plasma membrane to control neurotransmitter release in central synapses

    Dario Maschi et al.
    Synaptic vesicles undergo reversible tethering at the plasma membrane which is activity- and myosin V- dependent.
    1. Computational and Systems Biology
    2. Developmental Biology

    Elastic force restricts growth of the murine utricle

    Ksenia Gnedeva et al.
    Computational modeling and molecular-biological analysis reveal the role of mechanical force and downstream Yap signaling in growth control during the development and regeneration of sensory epithelium of the inner ear.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    The MBD7 complex promotes expression of methylated transgenes without significantly altering their methylation status

    Dongming Li et al.
    The METHYL-CpG-BINDING DOMAIN 7 (MBD7) complex promotes the activation (rather than repression) of transgenes that undergo DNA methylation and it does so without significantly altering their methylation status, placing this complex downstream of DNA methylation.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Co-option of an endogenous retrovirus envelope for host defense in hominid ancestors

    Daniel Blanco-Melo et al.
    The reconstitution of a functional envelope protein from an extinct hominid retrovirus reveals its receptor and an ancient host defense that may have led to the extinction of the virus.