3,874 results found
    1. Neuroscience

    Synaptic transmission and plasticity require AMPA receptor anchoring via its N-terminal domain

    Jake F Watson et al.
    The positioning of AMPA-type glutamate receptors at synapses – a requirement for effective neurotransmission and synaptic plasticity – is orchestrated by their extracellular, N-terminal domain.
    1. Chromosomes and Gene Expression

    MukB ATPases are regulated independently by the N- and C-terminal domains of MukF kleisin

    Katarzyna Zawadzka et al.
    In Escherichia coli structural maintenance of chromosomes (SMC) complex, MukBEF, a dimeric MukF kleisin binds and activates MukB SMC ATPases through two independent interfaces provided by distinct MukF N- and C-terminal domains.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A novel N-terminal extension in mitochondrial TRAP1 serves as a thermal regulator of chaperone activity

    James R Partridge et al.
    Cytosolic and organellar Hsp90s from higher eukaryotes have evolved a variable, and environmentally responsive N-terminal extension to regulate their activity.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Human LINE-1 retrotransposition requires a metastable coiled coil and a positively charged N-terminus in L1ORF1p

    Elena Khazina, Oliver Weichenrieder
    Human LINE-1 retrotransposition is found to critically depend on the rapidly evolving N-terminal sequence of the LINE-1 ORF1 protein and on the metastability of its coiled coil domain, indicating uncharacterized steps in LINE-1 retrotransposition.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Concerted regulation of ISWI by an autoinhibitory domain and the H4 N-terminal tail

    Johanna Ludwigsen et al.
    The N-terminal domain of the chromatin remodeler ISWI contains previously uncharacterized conserved motifs that maintain structure, prevent ATP hydrolysis unless nucleosomes are bound, and confer H4-tail sensitivity without directly competing with the H4 tail.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6

    Jennifer L Stamos et al.
    Phosphorylation of the Wnt receptor LRP6 directly inhibits glycogen synthase kinase-3 by acting as a pseudosubstrate that stabilizes an active conformation of the enzyme, identical to autoinhibition by phosphorylation of its N terminus.
    1. Plant Biology

    An N-terminal motif in NLR immune receptors is functionally conserved across distantly related plant species

    Hiroaki Adachi et al.
    The MADA motif is functionally conserved across NLRs from distantly related plants and has degenerated in sensor NLRs over evolutionary time.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    The Sec7 N-terminal regulatory domains facilitate membrane-proximal activation of the Arf1 GTPase

    Brian C Richardson et al.
    A new structure reveals two Arf-GEF regulatory domains form a single structural unit that stimulates Arf-GEF activity.
    1. Neuroscience

    The N-terminus of the prion protein is a toxic effector regulated by the C-terminus

    Bei Wu et al.
    A novel auto-inhibitory mechanism regulates the functional activity of the cellular prion protein, PrPC, providing for the first time a coherent molecular model for both its pathological and physiological effects.

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