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8,440 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization

    David Tse Shen Lin, Elizabeth Conibear
    Palmitate turnover is controlled by distinct enzyme families with different specificities.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A novel N-terminal extension in mitochondrial TRAP1 serves as a thermal regulator of chaperone activity

    James R Partridge et al.
    Cytosolic and organellar Hsp90s from higher eukaryotes have evolved a variable, and environmentally responsive N-terminal extension to regulate their activity.
    1. Neuroscience

    Formation of retinal direction-selective circuitry initiated by starburst amacrine cell homotypic contact

    Thomas A Ray et al.
    Selective synapse formation in a retinal motion-sensitive circuit is orchestrated by starburst amacrine cells, which use homotypic interactions to initiate formation of a dendritic scaffold that recruits projections from circuit partners.
    1. Neuroscience

    Feedback inhibition and its control in an insect olfactory circuit

    Subhasis Ray et al.
    Electrophysiological recordings and a large-scale biophysical model show that a unique inhibitory neuron plays a central role in structuring olfactory codes in the insect brain.
    1. Cell Biology

    Discrete spatial organization of TGFβ receptors couples receptor multimerization and signaling to cellular tension

    Joanna P Rys et al.
    Cells control the spatial organization and signaling of TGFβ receptors at focal adhesions via a mechanically regulated mechanism to integrate biochemical and physical cues.
    1. Neuroscience

    A prediction model of working memory across health and psychiatric disease using whole-brain functional connectivity

    Masahiro Yamashita et al.
    Human neuroimaging and machine learning reveals a generalizable relationship between brain connectivity and working memory ability across healthy populations and distinct psychiatric diagnoses.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Effective dynamics of nucleosome configurations at the yeast PHO5 promoter

    Michael Roland Wolff et al.
    The integration of multi-nucleosome configuration data with histone turnover and new chromatin accessibility data by systematically investigated 'regulated on-off-slide' models reveals promoter state transitions regulated by just one assembly process.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Structural insights into the architecture and membrane interactions of the conserved COMMD proteins

    Michael D Healy et al.
    A structural basis for the assembly of core subunits of the Commander Complex has been discovered.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    The homo-oligomerisation of both Sas-6 and Ana2 is required for efficient centriole assembly in flies

    Matthew A Cottee et al.
    The structure of the Ana2 Central Coiled-Coil Domain provides insight into how centriolar cartwheel components may be recruited and assembled, and indicates that cartwheel assembly involves more than just SAS-6 oligomerisation.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint

    Nicolas Bigot et al.
    Two phosphorylation sites on 53BP1 are found to mediate interaction with TOPBP1-RAD9 and shown to be essential for assembling the G1 DNA damage checkpoint response apparatus.

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