61 results found
    1. Microbiology and Infectious Disease

    Pathogen clonal expansion underlies multiorgan dissemination and organ-specific outcomes during murine systemic infection

    Karthik Hullahalli, Matthew K Waldor
    During Escherichia coli systemic infection, the replication of a minuscule fraction of the inoculum drives organ-specific clearance failures, systemic dissemination, and stochastic infection outcomes.
    1. Neuroscience

    Activation of mTORC1 and c-Jun by Prohibitin1 loss in Schwann cells may link mitochondrial dysfunction to demyelination

    Gustavo Della-Flora Nunes et al.
    mTORC1 and c-Jun are implicated in a possible mechanism causing myelin loss downstream of mitochondrial dysfunction in Schwann cells.
    1. Microbiology and Infectious Disease

    PGFinder, a novel analysis pipeline for the consistent, reproducible, and high-resolution structural analysis of bacterial peptidoglycans

    Ankur V Patel et al.
    PGFinder is an open-source software dedicated to the analysis of peptidoglycan mass spectrometry data that paves the way for peptidoglycomics.
    1. Microbiology and Infectious Disease

    Unexpected plasticity in the life cycle of Trypanosoma brucei

    Sarah Schuster et al.
    Parasite life cycles may be more flexible than traditionally thought, potentially allowing single-cell infections of insect vectors and transmission between hosts even at very low parasite densities.
    1. Neuroscience

    Localization, proteomics, and metabolite profiling reveal a putative vesicular transporter for UDP-glucose

    Cheng Qian et al.
    Identification of novel vesicular transporters will shed light on to expanding the chemical diversity of neurotransmitters or neuromodulators.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    BAP1/ASXL complex modulation regulates epithelial-mesenchymal transition during trophoblast differentiation and invasion

    Vicente Perez-Garcia et al.
    BAP1/ASXL is a key regulator of trophoblast invasion during early mouse and human placentation.
    1. Genetics and Genomics
    2. Neuroscience

    Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology

    Eric N Anderson et al.
    Traumatic injury leads to functional defects in nucleocytoplasmic transport and TDP-43 pathology in multiple model systems.
    1. Evolutionary Biology

    Reduced purine biosynthesis in humans after their divergence from Neandertals

    Vita Stepanova et al.
    Purine biosynthesis is reduced in humans due to a single amino acid substitution in adenylosuccinate lyase that occurred subsequent to the divergence of modern humans from Neandertals.
    1. Evolutionary Biology
    2. Immunology and Inflammation

    Glycan-based shaping of the microbiota during primate evolution

    Sumnima Singh et al.
    Ggta1 deletion in mice shapes and reduces the microbiota pathogenicity and probably contributed to the natural selection of GGTA1 loss-of-function mutations in the ancestral primates that gave rise to humans.
    1. Genetics and Genomics

    Genetic association and causal inference converge on hyperglycaemia as a modifiable factor to improve lung function

    William R Reay et al.
    Genetic data revealed existing drugs that could be repurposed to improve lung function, with evidence that compounds which control blood glucose could be particularly useful for respiratory impairment.

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