367 results found
    1. Cell Biology
    2. Neuroscience

    High N-glycan multiplicity is critical for neuronal adhesion and sensitizes the developing cerebellum to N-glycosylation defect

    Daniel Medina-Cano et al.
    Impairment of protein N-glycosylation disrupts neural cell adhesion mediated by highly glycosylated members of the IgSF-CAM protein family.
    1. Cell Biology
    2. Immunology and Inflammation

    Glycolysis and glutaminolysis cooperatively control T cell function by limiting metabolite supply to N-glycosylation

    Lindsey Araujo et al.
    Metabolic switches between oxidative phosphorylation and aerobic glycolysis plus glutaminolysis direct T cell function by altering the flux of glucose and glutamine to N-glycosylation.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    N-glycosylation in the protease domain of trypsin-like serine proteases mediates calnexin-assisted protein folding

    Hao Wang et al.
    N-glycans commonly present in the protease domains are required for calnexin-mediated protein folding and intracellular trafficking.
    1. Plant Biology

    Altered N-glycan composition impacts flagella-mediated adhesion in Chlamydomonas reinhardtii

    Nannan Xu et al.
    Adhesion force measurements reveal that proper N-glycosylation of flagellar membrane proteins is crucial for adhering C. reinhardtii cells onto surfaces.
    1. Microbiology and Infectious Disease

    Specificity in glycosylation of multiple flagellins by the modular and cell cycle regulated glycosyltransferase FlmG

    Silvia Ardissone et al.
    Glycosylation of flagellins with pseudaminic acid in the bacterial cytoplasm governed by an unknown type of modular glycosyltransferase harboring an N-terminal substrate binding domain and a C-terminal glycosyltransferase domain.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Golgi self-correction generates bioequivalent glycans to preserve cellular homeostasis

    Haik Mkhikian et al.
    Structurally dissimilar N-glycans can be functionally equivalent, and are produced via a self-correcting feature of the Golgi.
    1. Cell Biology
    2. Neuroscience

    Unconventional secretory processing diversifies neuronal ion channel properties

    Cyril Hanus et al.
    Imaging, quantitative immunoblotting and mass spectrometry reveal that hundreds of surface-expressed neuronal membrane proteins exhibit atypical glycosylation profiles, resulting in changes in protein half-life and synaptic responses.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Inhibition of SARS-CoV-2 viral entry upon blocking N- and O-glycan elaboration

    Qi Yang et al.
    A critical role for glycosylation on viral entry and methods to use this knowledge to reduce SARS-CoV-2 infectivity has been demonstrated.
    1. Cancer Biology
    2. Cell Biology

    Inhibitor of ppGalNAc-T3-mediated O-glycosylation blocks cancer cell invasiveness and lowers FGF23 levels

    Lina Song, Adam D Linstedt
    The first inhibitor identified against an iso-enzyme that initiates O-glycosylation in the Golgi complex promises new therapeutic approaches for cancer and chronic kidney disease.
    1. Cell Biology
    2. Developmental Biology

    Regulation of BMP4/Dpp retrotranslocation and signaling by deglycosylation

    Antonio Galeone et al.
    The cytoplasmic enzyme N-glycanase 1 plays an evolutionary conserved role in promoting the ERAD-mediated retrotranslocation of misfolded Dpp/BMP4 from the ER, thereby allowing BMP signaling in specific contexts.

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