5,690 results found
    1. Structural Biology and Molecular Biophysics

    Structural basis for human TRPC5 channel inhibition by two distinct inhibitors

    Kangcheng Song, Miao Wei ... Lei Chen
    The binding sites of two distinct TRPC5 inhibitors clemizole and HC-070 are revealed by cryo-EM.
    1. Neuroscience

    Human visual gamma for color stimuli

    Benjamin J Stauch, Alina Peter ... Pascal Fries
    Colored surfaces induce gamma oscillations in human early visual cortex that are equally strong for red and green colors when L-M cone contrast is controlled for.
    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor

    Neel H Shah, Qi Wang ... John Kuriyan
    A high-throughput technique to characterize the substrate specificities of tyrosine kinases identifies the key features of kinases and substrates that enforce accurate signaling from T cell receptors.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Antigenic evolution of human influenza H3N2 neuraminidase is constrained by charge balancing

    Yiquan Wang, Ruipeng Lei ... Nicholas C Wu
    The local fitness landscape of an antigenic region in influenza neuraminidase was determined by combinatorial mutagenesis and next-generation sequencing.
    1. Structural Biology and Molecular Biophysics

    Membrane curvature sensing and symmetry breaking of the M2 proton channel from Influenza A

    James Lincoff, Cole VM Helsell ... Michael Grabe
    Using a combination of all-atom molecular simulation and continuum membrane mechanics, M2 channels from influenza are shown to be stabilized in negative Gaussian curvature regions, such as the neck of budding viral particles, only in C2-symmetric conformations.
    1. Structural Biology and Molecular Biophysics

    Cystic fibrosis drug ivacaftor stimulates CFTR channels at picomolar concentrations

    László Csanády, Beáta Töröcsik
    Aqueous solubility of cystic fibrosis drug ivacaftor is ~200-fold lower, whereas the potency of its stimulatory effect on the CFTR channel is >100-fold higher, than reported, and is fully reversible.
    1. Neuroscience

    No relationship between frontal alpha asymmetry and depressive disorders in a multiverse analysis of five studies

    Aleksandra Kołodziej, Mikołaj Magnuski ... Aneta Brzezicka
    A multiverse approach consisting of 270 analyses on five independent studies fails to replicate the most common electrophysiological indicator of depression, which is asymmetry of alpha power in frontal regions.
  1. Episode 70: November 2020

    In this episode, we hear about artificial intelligence and in vitro fertilization, scar-free wound healing, decision-making, mosquitoes and open-access publishing.
  2. eLife welcomes 70 new editors in 14 subject areas

    eLife is pleased to announce 70 new editors joining our Board of Reviewing Editors (BRE) in 2016.
    1. Neuroscience

    Differential temporal dynamics during visual imagery and perception

    Nadine Dijkstra, Pim Mostert ... Marcel AJ van Gerven
    In contrast to perception, during visual imagery, there are no clear time-locked processing stages and imagery specifically overlaps with perceptual processing around 160 ms after stimulus onset and from 300 ms onwards.

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