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    1. Structural Biology and Molecular Biophysics

    RNA tertiary structure and conformational dynamics revealed by BASH MaP

    Maxim Oleynikov, Samie R Jaffrey
    BASH MaP quantitatively reveals alternative RNA tertiary structures by enabling dimethyl sulfate to probe the presence of nucleobase interactions on the Watson-Crick and Hoogsteen faces of single RNA molecules.
    1. Neuroscience

    Clusters of synaptic inputs on dendrites of layer 5 pyramidal cells in mouse visual cortex

    Onur Gökçe, Tobias Bonhoeffer, Volker Scheuss
    A combination of optogenetics and 2-photon calcium imaging reveals spatial prerequisites for non-linear synaptic summation within a defined cortical connection.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the bifunctional secretin complex of Thermus thermophilus

    Edoardo D'Imprima, Ralf Salzer ... Beate Averhoff
    The pilus extrusion/DNA uptake system of Thermus thermophilus contains a 13-mer of the 757-residue PilQ protein and a tightly bound protein outside the outer membrane with a role in DNA binding.
    1. Cell Biology
    2. Developmental Biology

    HSF-1 activates the ubiquitin proteasome system to promote non-apoptotic developmental cell death in C. elegans

    Maxime J Kinet, Jennifer A Malin ... Shai Shaham
    A pathway controlling non-apoptotic developmental cell death engages non-canonical death-promoting activities of the stress factor HSF-1, which, in turn, activates specific components of the ubiquitin-mediated degradation machinery.
    1. Neuroscience

    Active sensing in the categorization of visual patterns

    Scott Cheng-Hsin Yang, Máté Lengyel, Daniel M Wolpert
    Humans use a near-optimal eye movement strategy to efficiently extract information about high-level visual categories.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Nucleocapsid assembly in pneumoviruses is regulated by conformational switching of the N protein

    Max Renner, Mattia Bertinelli ... Jonathan M Grimes
    A structural comparison of different states of the protein responsible for encapsidation of the viral RNA genome provides mechanistic insights into this process.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Parallel evolution between genomic segments of seasonal human influenza viruses reveals RNA-RNA relationships

    Jennifer E Jones, Valerie Le Sage ... Seema S Lakdawala
    Phylogenetic relationships between viral RNA segments are distinct between subtypes and lineages of seasonal human influenza A viruses and implicate RNA-RNA relationships as novel drivers of influenza virus evolution.
    1. Cell Biology

    Regulation of the PI3K pathway through a p85α monomer–homodimer equilibrium

    Lydia WT Cheung, Katarzyna W Walkiewicz ... Gordon B Mills
    The p85α homodimer plays a role in the PI3K pathway by regulating PTEN function.
    1. Neuroscience

    Presynaptic NMDARs cooperate with local spikes toward GABA release from the reciprocal olfactory bulb granule cell spine

    Vanessa Lage-Rupprecht, Li Zhou ... Veronica Egger
    The essential role of presynaptic NMDA receptors for granule cell GABAergic output elucidates the function of reciprocal spines in recurrent and possibly lateral inhibition of mitral cells during olfactory processsing.