1,602 results found
    1. Microbiology and Infectious Disease

    A single regulator NrtR controls bacterial NAD+ homeostasis via its acetylation

    Rongsui Gao et al.
    Functional definition of NrtR and the discovery of its acetylation represents a first paradigm for linking protein acetylation to bacterial central NAD+ metabolism.
    1. Biochemistry and Chemical Biology

    Nicotinamide mononucleotide adenylyltransferase uses its NAD+ substrate-binding site to chaperone phosphorylated Tau

    Xiaojuan Ma et al.
    Mechanistic insight into the chaperone-like activity of NMNAT to phosphorylated Tau reveals a connection between NAD+metabolism and Tau homeostasis.
    1. Neuroscience

    NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion

    Yo Sasaki et al.
    Axonal metabolic flux analysis demonstrates that expression of NMNAT1 blocks axonal degeneration in cultured mouse neurons not by altering NAD+ synthesis, but rather by inhibiting injury-induced, SARM1-dependent NAD+ consumption.
    1. Cancer Biology
    2. Cell Biology

    NADPH oxidase-mediated redox signaling promotes oxidative stress resistance and longevity through memo-1 in C. elegans

    Collin Yvès Ewald et al.
    Genetic analysis reveals NADPH oxidase generated reactive oxygen species as signals to re-establish cellular homeostasis during aging via activating a transcriptional response.
    1. Cell Biology

    NADPH oxidase mediates microtubule alterations and diaphragm dysfunction in dystrophic mice

    James Anthony Loehr et al.
    Reative oxygen species modulate microtubules and diaphragm function.
    1. Chromosomes and Gene Expression

    Dual control of NAD+ synthesis by purine metabolites in yeast

    Benoît Pinson et al.
    Two distinct processes drive coordinated synthesis of purine and pyridine (NAD+) nucleotides in response to AICAR derivatives and ATP.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Highly efficient 5' capping of mitochondrial RNA with NAD+ and NADH by yeast and human mitochondrial RNA polymerase

    Jeremy G Bird et al.
    Eukaryotic mitochondrial RNA polymerases cap RNA with NAD with much higher efficiencies than nuclear RNA polymerase II; as a consequence, mitochondrial RNAs have remarkably high levels of NAD capping.
    1. Microbiology and Infectious Disease

    An NAD+-dependent novel transcription factor controls stage conversion in Entamoeba

    Dipak Manna et al.
    Cellular NAD+ levels change during stage conversion and regulate function of a novel transcription factor that controls developmental switching in the human pathogen Entamoeba histolytica.
    1. Neuroscience

    Expanded genetic screening in Caenorhabditis elegans identifies new regulators and an inhibitory role for NAD+ in axon regeneration

    Kyung Won Kim et al.
    A function-based genetic screen using the Caenorhabditis elegans axotomy model identifies new regulators and an inhibitory role for NAD+ in axon regeneration, expanding the understanding of axon injury responses and regeneration.
    1. Cell Biology

    Golgi localized β1-adrenergic receptors stimulate Golgi PI4P hydrolysis by PLCε to regulate cardiac hypertrophy

    Craig A Nash et al.
    β-adrenergic receptors at the Golgi apparatus activate a local signaling pathway, not accessed by cell surface receptors, to drive cardiac hypertrophy and could represent a target for heart failure therapy.

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