583 results found
    1. Structural Biology and Molecular Biophysics

    New tools for automated high-resolution cryo-EM structure determination in RELION-3

    Jasenko Zivanov, Takanori Nakane ... Sjors HW Scheres
    RELION-3 calculates single-particle reconstructions to higher resolution and with less user-interactions than previously available versions.
    1. Microbiology and Infectious Disease

    Thermosynechococcus switches the direction of phototaxis by a c-di-GMP-dependent process with high spatial resolution

    Daisuke Nakane, Gen Enomoto ... Takayuki Nishizaka
    Colour-controlled c-di-GMP signalling mediates directional switch of phototaxis via within-a-pole regulation of type IV pili in rod-shaped cyanobacteria Thermosynechococcus vulcanus.
    1. Chromosomes and Gene Expression

    The kinetochore prevents centromere-proximal crossover recombination during meiosis

    Nadine Vincenten, Lisa-Marie Kuhl ... Adèle L Marston
    The meiotic DNA recombination landscape is locally influenced by the kinetochore to minimize potentially deleterious pericentromeric crossover recombination.
    1. Evolutionary Biology

    Fog signaling has diverse roles in epithelial morphogenesis in insects

    Matthew Alan Benton, Nadine Frey ... Siegfried Roth
    Fog signaling with a narrow morphogenetic role in Drosophila has a deeply conserved function in epithelial morphogenesis across insects.
    1. Cell Biology
    2. Computational and Systems Biology

    Agent-based model demonstrates the impact of nonlinear, complex interactions between cytokines on muscle regeneration

    Megan Haase, Tien Comlekoglu ... Silvia S Blemker
    A computational model of skeletal muscle regeneration reveals complex interplay of cytokines, angiogenesis, and cell behaviors, predicting that synergistic cytokine perturbations enhance skeletal muscle regeneration beyond individual cytokine interventions.
    1. Chromosomes and Gene Expression

    Covalent linkage of the DNA repair template to the CRISPR-Cas9 nuclease enhances homology-directed repair

    Natasa Savic, Femke CAS Ringnalda ... Gerald Schwank
    Linking the DNA repair template to the Cas9 ribonucleoprotein complex enhances homology-directed repair of the induced DNA double strand break.
    1. Chromosomes and Gene Expression
    2. Physics of Living Systems

    Regulation of chromatin microphase separation by binding of protein complexes

    Omar Adame-Arana, Gaurav Bajpai ... Samuel Safran
    Chromatin-binding proteins regulate the effective solvent quality experienced by chromatin and impact global chromatin organization in the nucleus.
    1. Neuroscience

    Neural representations of naturalistic events are updated as our understanding of the past changes

    Asieh Zadbood, Samuel Nastase ... Uri Hasson
    Changes in the interpretation of specific scenes in a narrative trigger corresponding updates in the neural patterns evoked by those scenes in the default mode network.
    1. Genetics and Genomics
    2. Neuroscience

    Enrichment of SARM1 alleles encoding variants with constitutively hyperactive NADase in patients with ALS and other motor nerve disorders

    Jonathan Gilley, Oscar Jackson ... Michael P Coleman
    Rare SARM1 alleles encoding SARM1 variants that have constitutively high NADase activity and sensitise cultured neurons to mild stress are risk alleles for ALS and other, related motor disorders.
    1. Cell Biology

    Sex steroids regulate skin pigmentation through nonclassical membrane-bound receptors

    Christopher A Natale, Elizabeth K Duperret ... Todd W Ridky
    Two receptors have been identified that can be targeted in melanocytes with selective small molecule agonists to modulate human skin color.

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