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Activation of mTORC1 and c-Jun by Prohibitin1 loss in Schwann cells may link mitochondrial dysfunction to demyelination
Gustavo Della-Flora Nunes et al.
mTORC1 and c-Jun are implicated in a possible mechanism causing myelin loss downstream of mitochondrial dysfunction in Schwann cells.
mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice
Luke K Burke et al.
AGRP neurons integrate environmental food-related cues with internal metabolic signals to modulate interscapular brown adipose tissue thermogenesis and energy expenditure, at least in part, via mTORC1 signalling.
Recurrent circuit dynamics underlie persistent activity in the macaque frontoparietal network
Eric Hart, Alexander C Huk
Simultaneous recordings of neural ensembles in both the frontal and parietal cortices reveal how persistent activity can be maintained in the primate brain during visuospatial working memory.
Biochemistry and Chemical Biology
Semisynthetic biosensors for mapping cellular concentrations of nicotinamide adenine dinucleotides
Olivier Sallin et al.
A family of fluorescent biosensors for nicotinamide adenine dinucleotides allows quantification of these cofactors in live cells with spatio-temporal resolution.
Computational and Systems Biology
Immunology and Inflammation
Context-enriched interactome powered by proteomics helps the identification of novel regulators of macrophage activation
Arda Halu et al.
Enriching the interactome with context-specific information from proteomics helps the identification of novel regulators of macrophage activation.
Epidemiology and Global Health
Discovery proteomics in aging human skeletal muscle finds change in spliceosome, immunity, proteostasis and mitochondria
Ceereena Ubaida-Mohien et al.
The changes in the skeletal muscle proteome with age indicate the roots of the decline in muscle function with age.
Chromosomes and Gene Expression
Genetics and Genomics
MicroRNAs shape circadian hepatic gene expression on a transcriptome-wide scale
Ngoc-Hien Du et al.
In the liver, microRNAs exert widespread functions in the modulation of phases and amplitudes of clock-controlled gene expression, but their influence on the core clock is remarkably mild.
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