4,760 results found
    1. Cancer Biology

    The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer

    James D Joseph et al.
    GDC-0810 is a novel, orally bioavailable SERD that exhibits robust pre-clinical activity in models of ER+ breast cancer, including models of tamoxifen resistance, and those that express the ERα mutations, ER.Y537S and ER.D538G.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis

    Nicolas Altemose et al.
    In humans, specific sequence features can predict whether meiotic recombination occurs at sites bound by the protein PRDM9, whose DNA-binding zinc-finger domain can unexpectedly bind to gene promoters and to other copies of PRDM9.
    1. Biochemistry and Chemical Biology

    A surface proton antenna in carbonic anhydrase II supports lactate transport in cancer cells

    Sina Ibne Noor et al.
    Carbonic anhydrase II features a surface proton antenna that exclusively mediates proton exchange with monocarboxylate transporters to facilitate proton-coupled lactate transport in cancer cells.
    1. Cancer Biology
    2. Cell Biology

    Junction Mapper is a novel computer vision tool to decipher cell–cell contact phenotypes

    Helena Brezovjakova et al.
    Junction Mapper is a powerful new semi-automated software that provides a fingerprint of cell–cell contact morphometry and receptor density alterations.
    1. Cancer Biology
    2. Cell Biology

    Drosophila TRIM32 cooperates with glycolytic enzymes to promote cell growth

    Simranjot Bawa et al.
    TRIM32-mediated glycolytic flux generates precursors that are utilized for biomass production in non-dividing muscle, brain and tumor cells, demonstrating a universal metabolic function for TRIM32 in cell growth.
    1. Chromosomes and Gene Expression

    Tissue damage drives co-localization of NF-κB, Smad3, and Nrf2 to direct Rev-erb sensitive wound repair in mouse macrophages

    Dawn Z Eichenfield et al.
    Combinatorial signaling leads to transcription factor co-localization at Rev-erb sensitive enhancers, enabling a diversified cellular response to complex stimuli.
    1. Developmental Biology

    Segmentation of the zebrafish axial skeleton relies on notochord sheath cells and not on the segmentation clock

    Laura Lleras Forero et al.
    In contrast to amniotes, zebrafish (ray-finned fish, teleost) centra are formed from specialised notochord sheath cells, and the segmental patterning of these cells is independent of the segmentation clock.
    1. Biochemistry and Chemical Biology

    Control of the polyamine biosynthesis pathway by G2-quadruplexes

    Helen Louise Lightfoot et al.
    An ensemble of conserved G2-quadruplex structures in the untranslated regions of messenger RNAs from genes in the polyamine bioysynthesis pathway sense polyamine levels and regulate polyamine synthesis in cells.
    1. Cell Biology
    2. Neuroscience

    An alternative splicing switch shapes neurexin repertoires in principal neurons versus interneurons in the mouse hippocampus

    Thi-Minh Nguyen et al.
    Interneuron-specific alternative splice variants of the synaptic receptor neurexin are critical for hippocampal network activity and short-term memory.
    1. Evolutionary Biology
    2. Neuroscience

    Divergent sensory investment mirrors potential speciation via niche partitioning across Drosophila

    Ian W Keesey et al.
    Phototaxis and courtship behavioral preferences reflect strong correlation with differences in olfactory and visual nervous system investment across five monophyletic Drosophila species, and could help explain their speciation events.

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