Overexpression of VPS9D1-AS1 is a lncRNA to activate TGF-β and IFN signaling pathways, regulates crosstalk between cancer cells and T lymphocytes in the tumor microenvironment.
Chromosomal instability induced in solid tumors can combine with macrophages that are made highly phagocytic to thereby initiate elimination of and immunity against poorly immunogenic tumors in immunocompetent mice.
Raeann Goering, Ankita Arora ... J Matthew Taliaferro
Mechanisms that regulate RNA localization in one cell type predictably regulate RNA localization in other cell types, even if they have vastly different morphologies, implying an underlying regulatory code that cuts across specific subcellular structures.
Xenopus laevis arose from hybridization of two different frog species millions of years ago, leading to adaptation of the genetic networks controlling early embryonic development and stem cell induction to balance expression between the genes inherited from each ancestor.
Özgün Le Roux, Nicole LK Pershing ... Christopher M Counter
Altering the level of different oncogenic mutants of Kras induces unique tumor patterns in mice, suggesting that tissue-specific responses mold the sensitivity of normal tissues to different oncogenic RAS mutations.
Ubiquitous transcriptional factor-CBP/p300 interaction induces epigenetic and transcriptional bimodality, which can be utilized to tune mean gene expression and noise independently.
A detailed analysis of protein abundance and phosphorylation changes across mitotic subphases and interphase in asynchronously growing human cells has been enabled by combining FACS with quantitative MS-based proteomics.
Rosalyn W Sayaman, Masaru Miyano ... Mark A LaBarge
Breast luminal epithelial cells are the hotspots of aging-associated changes, which prime aged epithelia for oncogenic gene activation and may explain individual differences in breast cancer susceptibility due to the aging-associated increase in gene expression variances in luminal epithelia.
The LIM-homedomain transcription factor Lhx2 confers competence to retinal progenitor cells to activate and maintain Sonic Hedgeghog signaling at physiological levels during a key phase of tissue growth and cell type generation.
