130 results found
    1. Cell Biology
    2. Neuroscience

    TDP-43 maximizes nerve conduction velocity by repressing a cryptic exon for paranodal junction assembly in Schwann cells

    Kae-Jiun Chang et al.
    Glial TDP-43 regulates splicing and expression of neurofascin and is required for proper assembly and maintenance of paranodal axoglial junctions.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    HAT cofactor TRRAP modulates microtubule dynamics via SP1 signaling to prevent neurodegeneration

    Alicia Tapias et al.
    The Trrap-HAT-Sp1 axis operates a conserved transcriptional program to control proper microtubule dynamics in brain homeostasis and prevents neurodegeneration.
    1. Neuroscience

    Control of feeding by Piezo-mediated gut mechanosensation in Drosophila

    Soohong Min et al.
    Gut-innervating sensory neurons detect large food volumes and inhibit feeding in Drosophila through the mechanically gated ion channel Piezo.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Foxc1 establishes enhancer accessibility for craniofacial cartilage differentiation

    Pengfei Xu et al.
    Foxc1 proteins prepare the genomes of neural crest-derived cells to facilitate their later development into the cartilages that support the embryonic face.
    1. Immunology and Inflammation

    Gut Helicobacter presentation by multiple dendritic cell subsets enables context-specific regulatory T cell generation

    Emilie V Russler-Germain et al.
    In vitro and in vivo studies show that multiple dendritic cell subsets are capable of presenting gut Helicobacter antigens to induce regulatory T cells.
    1. Immunology and Inflammation

    Induction of the IL-1RII decoy receptor by NFAT/FOXP3 blocks IL-1β-dependent response of Th17 cells

    Dong Hyun Kim et al.
    Cellular immunological and biochemical analyses reveal how decoy IL-1RII is induced by human CD4+ T cells upon TCR-stimulation and regulates the Th17-Treg balance by modulating IL-1β responsiveness in IL-1RI+ cells.
    1. Immunology and Inflammation

    Peripheral natural killer cells in chronic hepatitis B patients display multiple molecular features of T cell exhaustion

    Marie Marotel et al.
    Similar to T cell exhaustion, natural killer cell dysfunction in chronic hepatitis B patients results from deregulated calcium pathway.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Single-cell RNA-seq reveals transcriptomic heterogeneity mediated by host–pathogen dynamics in lymphoblastoid cell lines

    Elliott D SoRelle et al.
    Single-cell RNA sequencing highlights the influence of host–pathogen interactions and stochasticity on transcriptional and phenotypic variance in lymphoblastoid cell lines derived from Epstein–Barr virus-infected primary B cells.
    1. Developmental Biology

    Reciprocal interaction between mesenchymal stem cells and transit amplifying cells regulates tissue homeostasis

    Junjun Jing et al.
    The molecular regulatory mechanisms that control the interaction between mesenchymal stem cells and transit amplifying cells to maintain tissue homeostasis.
    1. Neuroscience

    Cytosolic calcium regulates cytoplasmic accumulation of TDP-43 through Calpain-A and Importin α3

    Jeong Hyang Park et al.
    Genetic and optogenetic analyses in Drosophila neurons reveal calcium as one of the key regulators of nucleocytoplasmic localization of TDP-43 via Calpain-A and Importin α3.

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