Telomere-sensitive regulation of IL1R1 by the shelterin protein TERF2 modulates tumour macrophage inflitration in triple-negative breast cancer.

Evidence is provided suggesting that heterochromatin re-organisation during cell senescence can compromise the structural integrity of the nucleus, leading to activation of an inflammatory process.

Loss-of-function variants of human ACK1 and BRK kinase underlie systemic lupus erythematosus in young patients from multiplex families and disrupt the anti-inflammatory response of macrophages to apoptotic cells.

FABP4 plays a central role in driving the formation lipid-laden macrophages induced by unsaturated fats and enhances macrophage-tumor interactions, thereby promoting breast cancer migration and metastasis.

A live imaging and computational approach reveals feedback loops involving F-actin dynamics that regulate the NF-κB transcription factor RELA.

Studies of heterogeneity in healthy brain aging reveal varying susceptibilities to aging and delayed development, which deepen aging-development understanding and promote prediction and diagnosis of cognitive decline and neurodegenerative diseases.

Molecular and biochemical approaches in primary human cells illustrate how a nuclear RNA-binding protein is shifted to the surface of osteoclasts – setting their size and biological activity.