57 results found
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Persistence, period and precision of autonomous cellular oscillators from the zebrafish segmentation clock

    Alexis B Webb, Iván M Lengyel ... Andrew C Oates
    Time-lapse recording and theoretical analysis of individual cells isolated from the zebrafish segmentation clock reveal that they behave as self-sustained, autonomous oscillators with distinctive noisy dynamics.
    1. Immunology and Inflammation

    Natural killer (NK) cell-derived extracellular-vesicle shuttled microRNAs control T cell responses

    Sara G Dosil, Sheila Lopez-Cobo ... Lola Fernandez-Messina
    Extracellular vesicles derived from natural killer cells contain a specific repertoire of microRNAs that promote Th1 responses.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Hydrogen sulfide blocks HIV rebound by maintaining mitochondrial bioenergetics and redox homeostasis

    Virender Kumar Pal, Ragini Agrawal ... Amit Singh
    A gaseous signaling molecule hydrogen sulfide stimulates mitochondrial bioenergetics, maintains glutathione redox poise, and suppresses ROS to subvert viral rebound in latently infected CD4+ T cells from HIV subjects.
    1. Immunology and Inflammation

    A highly conserved host lipase deacylates oxidized phospholipids and ameliorates acute lung injury in mice

    Benkun Zou, Michael Goodwin ... Mingfang Lu
    Acyloxyacyl hydrolase, the host lipase that detoxifies bacterial lipopolysaccharides, also deacylates oxidized phospholipids, preventing inflammasome activation in macrophages in vitro and ameliorating acute lung injury in vivo.
    1. Developmental Biology

    The autophagy protein, ATG14 safeguards against unscheduled pyroptosis activation to enable embryo transport during early pregnancy

    Pooja Popli, Arin K Oestreich ... Ramakrishna Kommagani
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Dynamic chromatin architecture identifies new autoimmune-associated enhancers for IL2 and novel genes regulating CD4+ T cell activation

    Matthew C Pahl, Prabhat Sharma ... Andrew D Wells
    The three-dimensional architecture of the genome in distinct cell types predicts genes and regulatory elements involved in cell function and disease.
    1. Immunology and Inflammation

    Reversible promoter methylation determines fluctuating expression of acute phase proteins

    Shi-Chao Zhang, Ming-Yu Wang ... Yi Wu
    DNA methylation status can be exploited to finely and reversibly tune the expression of highly inducible genes with CpG-poor promoters in response to environmental cues.
    1. Immunology and Inflammation
    2. Neuroscience

    Cystatin F (Cst7) drives sex-dependent changes in microglia in an amyloid-driven model of Alzheimer’s disease

    Michael JD Daniels, Lucas Lefevre ... Barry W McColl
    Cst7, a gene coding for protein cystatin F, is expressed by microglia in neurodegenerative disease models and mediates sex-dependent effects on microglial endolysosomal function and disease pathology.
    1. Microbiology and Infectious Disease

    Structure–function analysis of Lactiplantibacillus plantarum DltE reveals D-alanylated lipoteichoic acids as direct cues supporting Drosophila juvenile growth

    Nikos Nikolopoulos, Renata C Matos ... François Leulier
    D-alanylated lipoteichoic acids support Drosophila juvenile growth.
    1. Genetics and Genomics

    Functional characterization of the disease-associated CCL2 rs1024611G-rs13900T haplotype: The role of the RNA-binding protein HuR

    Feroz Akhtar, Joselin Hernandez Ruiz ... Srinivas Mummidi
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid

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