2,872 results found
    1. Neuroscience

    NG2 glial cells integrate synaptic input in global and dendritic calcium signals

    Wenjing Sun et al.
    NG2 glial cells respond to synaptic input with calcium signals in the absence of action potentials and process synaptic depolarizations with somatic and dendritic voltage gated channels.
    1. Cell Biology
    2. Developmental Biology

    JNK-dependent cell cycle stalling in G2 promotes survival and senescence-like phenotypes in tissue stress

    Andrea Cosolo et al.
    Tissue damage induces a reversible cell cycle arrest in G2, which promotes survival and mitogenic signals to facilitate tissue regeneration but drives senescence-like phenotypes under chronic stress conditions.
    1. Neuroscience

    Synapse maintenance and restoration in the retina by NGL2

    Florentina Soto et al.
    Single cell knockout and overexpression reveal that the synaptic cell adhesion molecule NGL2 maintains synapses and axons, and can restore lost connections in the developing and mature retina.
    1. Neuroscience

    PTEN negatively regulates the cell lineage progression from NG2+ glial progenitor to oligodendrocyte via mTOR-independent signaling

    Estibaliz González-Fernández et al.
    OPC-specific genetic inhibition of Akt upstream and downstream molecules in the mouse, and simultaneous OPC fate analysis reveal that PTEN-AKT-GSK3b forms a persistent negative signaling pathway for OL development, in parallel with the AKT-mTORC1 pathway.
    1. Neuroscience

    Interneurons and oligodendrocyte progenitors form a structured synaptic network in the developing neocortex

    David Orduz et al.
    During the second postnatal week, a temporary circuit made up of specific types of neurons plus the precursors of oligodendrocytes is established in the brain, and may promote the maturation of oligodendrocytes in preparation for myelination.
    1. Plant Biology

    A regulatory module controlling stress-induced cell cycle arrest in Arabidopsis

    Naoki Takahashi et al.
    Arabidopsis deploys the core signalling module that perceives distinct stress signals, such as DNA damage and heat stresses, and represses G2/M-specific genes, thereby causing cell cycle arrest.
    1. Neuroscience

    NG2 glia are required for vessel network formation during embryonic development

    Shilpi Minocha et al.
    The appearance of NG2+ glial cells in the dorsal telencephalon of the embryo coincides with the establishment of the brain blood vessel network in mice.
    1. Biochemistry and Chemical Biology

    Control of the polyamine biosynthesis pathway by G2-quadruplexes

    Helen Louise Lightfoot et al.
    An ensemble of conserved G2-quadruplex structures in the untranslated regions of messenger RNAs from genes in the polyamine bioysynthesis pathway sense polyamine levels and regulate polyamine synthesis in cells.
    1. Plant Biology

    Fluctuations of the transcription factor ATML1 generate the pattern of giant cells in the Arabidopsis sepal

    Heather M Meyer et al.
    Fluctuations of a transcription factor that coincide with the G2 phase of the cell cycle pattern two interspersed cell fates in a multicellular system.
    1. Neuroscience

    Multivesicular bodies mediate long-range retrograde NGF-TrkA signaling

    Mengchen Ye et al.
    Multivesicular bodies deliver long-range retrograde nerve growth factor (NGF) signals and serve as essential signaling and sorting platforms in the cell soma, and multivesicular body (MVB) cargoes dictate their vesicular fate.

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