1,266 results found
    1. Neuroscience

    NG2 glial cells integrate synaptic input in global and dendritic calcium signals

    Wenjing Sun et al.
    NG2 glial cells respond to synaptic input with calcium signals in the absence of action potentials and process synaptic depolarizations with somatic and dendritic voltage gated channels.
    1. Cell Biology
    2. Developmental Biology

    JNK-dependent cell cycle stalling in G2 promotes survival and senescence-like phenotypes in tissue stress

    Andrea Cosolo et al.
    Tissue damage induces a reversible cell cycle arrest in G2, which promotes survival and mitogenic signals to facilitate tissue regeneration but drives senescence-like phenotypes under chronic stress conditions.
    1. Neuroscience

    Interneurons and oligodendrocyte progenitors form a structured synaptic network in the developing neocortex

    David Orduz et al.
    During the second postnatal week, a temporary circuit made up of specific types of neurons plus the precursors of oligodendrocytes is established in the brain, and may promote the maturation of oligodendrocytes in preparation for myelination.
    1. Neuroscience

    Synapse maintenance and restoration in the retina by NGL2

    Florentina Soto et al.
    Single cell knockout and overexpression reveal that the synaptic cell adhesion molecule NGL2 maintains synapses and axons, and can restore lost connections in the developing and mature retina.
    1. Neuroscience

    NG2 glia are required for vessel network formation during embryonic development

    Shilpi Minocha et al.
    The appearance of NG2+ glial cells in the dorsal telencephalon of the embryo coincides with the establishment of the brain blood vessel network in mice.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Regenerative neurogenic response from glia requires insulin-driven neuron-glia communication

    Neale J Harrison et al.
    Neuronal Ia-2 and glial Kon coordinate an injury-response insulin relay that restores glial cell populations and induces neural stem cells from glia, enabling central nervous system regeneration.
    1. Neuroscience

    PTEN negatively regulates the cell lineage progression from NG2+ glial progenitor to oligodendrocyte via mTOR-independent signaling

    Estibaliz González-Fernández et al.
    OPC-specific genetic inhibition of Akt upstream and downstream molecules in the mouse, and simultaneous OPC fate analysis reveal that PTEN-AKT-GSK3b forms a persistent negative signaling pathway for OL development, in parallel with the AKT-mTORC1 pathway.
    1. Neuroscience

    Multivesicular bodies mediate long-range retrograde NGF-TrkA signaling

    Mengchen Ye et al.
    Multivesicular bodies deliver long-range retrograde nerve growth factor (NGF) signals and serve as essential signaling and sorting platforms in the cell soma, and multivesicular body (MVB) cargoes dictate their vesicular fate.
    1. Cell Biology
    2. Computational and Systems Biology

    Multiple inputs ensure yeast cell size homeostasis during cell cycle progression

    Cecilia Garmendia-Torres et al.
    Yeast cell size homeostasis is not controlled by a G1-specific mechanism alone but is likely to be an emergent property resulting from the integration of several mechanisms that coordinate cell and bud growth with division.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Herpes simplex viral nucleoprotein creates a competitive transcriptional environment facilitating robust viral transcription and host shut off

    Sarah E Dremel, Neal A DeLuca
    Herpes simplex ICP4 preferentially binds to and delineates the viral genome, ultimately resulting in robust viral transcription at the expense of the host.

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