13 results found
    1. Cell Biology

    Glucose restriction drives spatial reorganization of mevalonate metabolism

    Sean Rogers et al.
    Genetic and biochemical analyses, coupled with fluorescence imaging, reveal that spatial compartmentalization of HMG-CoA Reductases at yeast ER-lysosome contacts modulates mevalonate pathway flux during glucose restriction, enabling metabolic adaptation.
    1. Cell Biology
    2. Genetics and Genomics

    A Drosophila screen identifies NKCC1 as a modifier of NGLY1 deficiency

    Dana M Talsness et al.
    An ion transporter is hyperglycosylated and 50% less functional in NGLY1-deficient cells, potentially explaining several symptoms of NGLY1 deficiency such as lack of sweat and tears.
    1. Cell Biology
    2. Developmental Biology

    Regulation of BMP4/Dpp retrotranslocation and signaling by deglycosylation

    Antonio Galeone et al.
    The cytoplasmic enzyme N-glycanase 1 plays an evolutionary conserved role in promoting the ERAD-mediated retrotranslocation of misfolded Dpp/BMP4 from the ER, thereby allowing BMP signaling in specific contexts.
    1. Computational and Systems Biology

    Science Forum: Wikidata as a knowledge graph for the life sciences

    Andra Waagmeester et al.
    Wikidata is continuously-updated resource that could improve the efficiency and accuracy of research in many areas of the life and biomedical sciences.
    1. Cell Biology
    2. Genetics and Genomics

    Endoplasmic reticulum-associated SKN-1A/Nrf1 mediates a cytoplasmic unfolded protein response and promotes longevity

    Nicolas J Lehrbach, Gary Ruvkun
    SKN-1A/Nrf1 promotes healthy aging by activating protein degradation in response to accumulation of misfolded proteins.
    1. Developmental Biology

    Guy1, a Y-linked embryonic signal, regulates dosage compensation in Anopheles stephensi by increasing X gene expression

    Yumin Qi et al.
    For the first time in a mosquito species an initial Y chromosome signal has been shown to regulate dosage compensation by increasing X chromosome gene expression.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Genetic analysis reveals functions of atypical polyubiquitin chains

    Fernando Meza Gutierrez et al.
    A comprehensive genetic interaction screen uncovered biological roles of K11 linkages in amino acid homeostasis and cell cycle regulation in yeast.
    1. Neuroscience

    Pre-post synaptic alignment through neuroligin-1 tunes synaptic transmission efficiency

    Kalina T Haas et al.
    Neuroligin 1 is a critical adhesion molecule which organizes AMPA receptor nanodomains in close vicinity to pre-synaptic release sites, and whose genetic or chemical disruption severely impairs synaptic transmission properties.
    1. Neuroscience

    Neurexin and Neuroligin-based adhesion complexes drive axonal arborisation growth independent of synaptic activity

    William D Constance et al.
    Axonal arborisation growth is regulated by dynamic, focal localisations of Neurexin and Neuroligin that provide stability for filopodia, enabling a 'stick and grow'-based mechanism, wholly independent of synapse formation.
    1. Developmental Biology

    Tissue-specific regulation of BMP signaling by Drosophila N-glycanase 1

    Antonio Galeone et al.
    N-glycanase 1 is required for a BMP autoregulatory loop in the visceral mesoderm and for intestinal development in Drosophila.

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