385 results found
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Dynamic Na+/H+ exchanger 1 (NHE1) – calmodulin complexes of varying stoichiometry and structure regulate Ca2+-dependent NHE1 activation

    Lise M Sjøgaard-Frich et al.
    NHE1-CaM complexes of multiple stoichiometries regulate cellular Ca2+-dependent NHE1 activity and can contribute to NHE1 dimerization, the latter shown by the NMR structure of CaM linking two NHE1 cytosolic tails.
    1. Neuroscience

    Reversal of ApoE4-induced recycling block as a novel prevention approach for Alzheimer’s disease

    Xunde Xian et al.
    Lowering endosomal pH through inhibition of sodium-hydrogen exchanger 6 corrects the ApoE4-induced Reelin resistance and restores neuronal glutamate receptor trafficking.
    1. Genetics and Genomics

    One-step efficient generation of dual-function conditional knockout and geno-tagging alleles in zebrafish

    Wenyuan Li et al.
    Conditional gene knockout in combination with fluorescent labeling of different alleles can be achieved with high efficiency in zebrafish through NHEJ-mediated targeted insertion using a CRISPR/Cas system.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Mutational phospho-mimicry reveals a regulatory role for the XRCC4 and XLF C-terminal tails in modulating DNA bridging during classical non-homologous end joining

    Davide Normanno et al.
    In concert phosphorylation site modification of both XRCC4 and XLF C-terminal disordered tails promotes disassembly of XRCC4/XLF DNA tethers during c-NHEJ.
    1. Cell Biology
    2. Genetics and Genomics

    A high-throughput small molecule screen identifies farrerol as a potentiator of CRISPR/Cas9-mediated genome editing

    Weina Zhang et al.
    Farrerol promotes the efficiency of CRISPR/Cas9-mediated genome editing in both cells and embryos.
    1. Chromosomes and Gene Expression

    Nucleosome disassembly during human non-homologous end joining followed by concerted HIRA- and CAF-1-dependent reassembly

    Xuan Li, Jessica K Tyler
    The human genome is unpackaged to allow DNA breaks to be joined back together, and then repackaged into chromosomes afterwards.
    1. Cell Biology
    2. Cancer Biology

    Increased H+ efflux is sufficient to induce dysplasia and necessary for viability with oncogene expression

    Bree K Grillo-Hill et al.
    Increasing the internal pH of cells can induce dysplasia and enhance oncogene-increased cell growth, while decreasing the internal pH combined with oncogene expression leads to synthetic lethality.
    1. Cell Biology

    Kinesin Kif2C in regulation of DNA double strand break dynamics and repair

    Songli Zhu et al.
    Kinesin Kif2C is recruited to DNA damage sites, modulates the mobility and dynamics of DNA damage foci, and promotes DNA double strand break repair.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    XLF acts as a flexible connector during non-homologous end joining

    Sean M Carney et al.
    The disordered C-terminal tail allows XRCC4-like factor (XLF) to find and bind the XRCC4-Lig4 complex, enabling DNA end synapsis and subsequent ligation during non-homologous end joining.
    1. Chromosomes and Gene Expression

    Catastrophic chromosomal restructuring during genome elimination in plants

    Ek Han Tan et al.
    Complex chromosomal rearrangements similar to those described in cancer and developmental syndromes occur in plants during postzygotic genome elimination, a centromeric-derived incompatibility.

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