155 results found
    1. Immunology and Inflammation

    Toxoplasma gondii infection drives conversion of NK cells into ILC1-like cells

    Eugene Park et al.
    Toxoplasma gondii infection leads to conversion of natural killer cells into cells resembling innate lymphoid cells, group 1, that circulate widely, disrupting current notions suggesting that these cells have distinct lineages.
    1. Cancer Biology
    2. Immunology and Inflammation

    Endothelial cells express NKG2D ligands and desensitize antitumor NK responses

    Thornton W Thompson et al.
    Antitumor (natural killer) NK cell responses are negatively regulated by interactions between NK cells and endogenous NKG2D ligands constitutively expressed on lymph node endothelial cells and super-induced on tumor-associated endothelium.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A herpesvirus encoded Qa-1 mimic inhibits natural killer cell cytotoxicity through CD94/NKG2A receptor engagement

    Xiaoli Wang et al.
    Rodent herpesvirus Peru overcomes NK ‘missing-self’ killing using a non-classical MHC-I like protein resistant todownregulation by its own ubiquitin ligase that potently sabotages antigen presentation to T-cells.
    1. Immunology and Inflammation

    mTORC1 and mTORC2 differentially promote natural killer cell development

    Chao Yang et al.
    mTORC1 and mTORC2 play a central role in the development of natural killer (NK) cells.
    1. Immunology and Inflammation

    Tissue-resident natural killer (NK) cells are cell lineages distinct from thymic and conventional splenic NK cells

    Dorothy K Sojka et al.
    Natural killer cells that were commonly thought to circulate around the body can actually reside in distinct tissues, such as in the liver, skin or uterus, and do not re-circulate.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    NK cells inhibit Plasmodium falciparum growth in red blood cells via antibody-dependent cellular cytotoxicity

    Gunjan Arora et al.
    Red blood cells infected by the malaria parasite Plasmodium falciparum are destroyed by human natural killer cells in the presence of antibodies from people who have acquired clinical immunity to malaria.
    1. Immunology and Inflammation

    Cancer: How the immune system spots tumors

    Yasutaka Okabe, Ruslan Medzhitov
    Insight
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    1. Immunology and Inflammation

    Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses

    Shiho Chiba et al.
    An immune system pattern recognition receptor potentiates anti-tumor innate immune responses, offering new insight into anti-tumor activity of the innate immune system.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A Herpesviral induction of RAE-1 NKG2D ligand expression occurs through release of HDAC mediated repression

    Trever T Greene et al.
    Viral infection can induce NKG2D ligand expression through the action of virally encoded histone deacetylase (HDAC) inhibitors, which release HDAC mediated repression of NKG2D ligands.
    1. Neuroscience

    Environmental stimuli shape microglial plasticity in glioma

    Stefano Garofalo et al.
    The microenvironment of brain tumors can be modulated by in vivo conditions that change the brain levels of BDNF and IL-15, with effects on innate immune cell activation.

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