228 results found
    1. Immunology and Inflammation

    Umbilical cord blood-derived ILC1-like cells constitute a novel precursor for mature KIR+NKG2A- NK cells

    Sabrina Bianca Bennstein et al.
    Neonatal ILC1-like cells are functionally immature but have the unique potential to generate NK cells characterized by downregulation of NKG2A and a highly diverse KIR receptor repertoire.
    1. Immunology and Inflammation

    Single-cell transcriptome reveals the novel role of T-bet in suppressing the immature NK gene signature

    Chao Yang et al.
    T-bet suppresses the expression of immature NK cell-defining genes.
    1. Immunology and Inflammation

    Tumor control via targeting PD-L1 with chimeric antigen receptor modified NK cells

    Yvette Robbins et al.
    Human NK cells engineered to express a PD-L1 chimeric antigen receptor can control murine and human tumors and reduce myeloid cells expressing high levels of PD-L1.
    1. Immunology and Inflammation

    Toxoplasma gondii infection drives conversion of NK cells into ILC1-like cells

    Eugene Park et al.
    Toxoplasma gondii infection leads to conversion of natural killer cells into cells resembling innate lymphoid cells, group 1, that circulate widely, disrupting current notions suggesting that these cells have distinct lineages.
    1. Cancer Biology
    2. Immunology and Inflammation

    Endothelial cells express NKG2D ligands and desensitize antitumor NK responses

    Thornton W Thompson et al.
    Antitumor (natural killer) NK cell responses are negatively regulated by interactions between NK cells and endogenous NKG2D ligands constitutively expressed on lymph node endothelial cells and super-induced on tumor-associated endothelium.
    1. Cancer Biology
    2. Computational and Systems Biology

    Identifying prostate cancer and its clinical risk in asymptomatic men using machine learning of high dimensional peripheral blood flow cytometric natural killer cell subset phenotyping data

    Simon P Hood et al.
    Diagnosing the presence and clinical significance of prostate cancer can be achieved using AI-based analysis of peripheral blood natural killer (NK) cell subset profiles.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A herpesvirus encoded Qa-1 mimic inhibits natural killer cell cytotoxicity through CD94/NKG2A receptor engagement

    Xiaoli Wang et al.
    Rodent herpesvirus Peru overcomes NK ‘missing-self’ killing using a non-classical MHC-I like protein resistant todownregulation by its own ubiquitin ligase that potently sabotages antigen presentation to T-cells.
    1. Immunology and Inflammation

    mTORC1 and mTORC2 differentially promote natural killer cell development

    Chao Yang et al.
    mTORC1 and mTORC2 play a central role in the development of natural killer (NK) cells.
    1. Cell Biology
    2. Immunology and Inflammation

    Metabolic but not transcriptional regulation by PKM2 is important for natural killer cell responses

    Jessica F Walls et al.
    Pharmacological activation of the metabolic activities of PKM2 in murine NK cells disrupts cellular redox balance and inhibits optimal NK cell effector functions.
    1. Cell Biology
    2. Immunology and Inflammation

    CD56 regulates human NK cell cytotoxicity through Pyk2

    Justin T Gunesch et al.
    CD56/NCAM, the prototypical marker of human natural killer cells, promotes lytic function towards susceptible target cells by signaling through protein tyrosine kinase 2 (Pyk2).

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