1,997 results found
    1. Plant Biology
    2. Structural Biology and Molecular Biophysics

    Protein engineering expands the effector recognition profile of a rice NLR immune receptor

    Juan Carlos De la Concepcion et al.
    Structure-led protein engineering can expand the effector recognition profile of plant intracellular NLR immune receptors, providing a proof-of-principle for the development of novel disease resistance mechanisms in plants.
    1. Immunology and Inflammation

    Broad and direct interaction between TLR and Siglec families of pattern recognition receptors and its regulation by Neu1

    Guo-Yun Chen et al.
    Sialoside-based pattern recognition by Siglecs directly regulates toll-like receptor signaling and a sialidase inhibitor protects against endotoxemia.
    1. Structural Biology and Molecular Biophysics
    2. Plant Biology

    Structural basis of pathogen recognition by an integrated HMA domain in a plant NLR immune receptor

    A Maqbool et al.
    Structure/function studies of a plant pathogen effector in complex with a host disease resistance protein domain reveal the molecular basis for recognition and underpin future engineering of immunity in crops.
    1. Plant Biology

    Multiple pairs of allelic MLA immune receptor-powdery mildew AVRA effectors argue for a direct recognition mechanism

    Isabel ML Saur et al.
    Allelic MLA immune receptors have an exceptional propensity to directly detect sequence-unrelated pathogen effectors and this feature might have facilitated functional diversification of the receptor in the host population.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases

    Huaibin Chen et al.
    A four-switch long-range allosteric network controls FGF receptor kinase conformational dynamics as well as activity and is applicable to other receptor tyrosine kinases.
    1. Plant Biology

    Regulation of plant immune receptor accumulation through translational repression by a glycine-tyrosine-phenylalanine (GYF) domain protein

    Zhongshou Wu et al.
    A GYF protein regulates plant immune receptor homeostasis through translational repression, a previously unknown mechanism.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis of death domain signaling in the p75 neurotrophin receptor

    Zhi Lin et al.
    Structures of the death domain of the p75 neurotrophin receptor in complex with downstream effectors show how competitive protein-protein interactions orchestrate the hierarchical activation of downstream pathways in non-catalytic receptors.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Activation of Toll-like receptors nucleates assembly of the MyDDosome signaling hub

    Sarah Louise Latty et al.
    The strength of Toll-like receptor signalling depends on the number and size of MyDDosomes formed as well as on how quickly these structures assemble.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Ligand modulation of sidechain dynamics in a wild-type human GPCR

    Lindsay D Clark et al.
    Generation of a highly deuterated 13C-methyl labeled wild-type GPCR sample is used to facilitate characterization of the molecular environments and fast ps-ns dynamics of sidechains when the receptor is bound to ligands of different efficacy.
    1. Cell Biology
    2. Neuroscience

    Hypoxia-inducible factor cell non-autonomously regulates C. elegans stress responses and behavior via a nuclear receptor

    Corinne L Pender, H Robert Horvitz
    The hypoxia-inducible factor HIF drives transcription of the gene cyp-36A1, which encodes a cytochrome P450 enzyme that acts via a putative intercellular signal to regulate the nuclear receptor NHR-46 and consequently stress resistance and behavior.

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