624 results found
    1. Neuroscience

    Physiological and pathophysiological control of synaptic GluN2B-NMDA receptors by the C-terminal domain of amyloid precursor protein

    Paula A Pousinha et al.
    The APP intracellular domain (AICD) physiologically regulates synaptic GluN2B-containing NMDA receptor current, a process that could contribute to pathological Alzheimer's disease-related synaptic failure upon increase of AICD levels in adult neurons.
    1. Neuroscience

    Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of Dapk1

    Jamie McQueen et al.
    Excitotoxicity driven by NMDA receptor hyper-activation does not involve DAPK1-dependent events in vitro or in vivo, and previously described DAPK1-NMDAR disrupting peptides act by blocking the NMDA receptor.
    1. Neuroscience

    A circuit mechanism for decision-making biases and NMDA receptor hypofunction

    Sean Edward Cavanagh et al.
    Ketamine, an NMDA receptor antagonist and experimental model for schizophrenia, produces decision-making deficits in monkeys, which are predicted by a lowering of cortical excitation-inhibition balance in a spiking circuit model.
    1. Neuroscience

    Presynaptic PTPσ regulates postsynaptic NMDA receptor function through direct adhesion-independent mechanisms

    Kyungdeok Kim et al.
    Presynaptic adhesion molecule PTPσ in the hippocampus regulates postsynaptic NMDA receptor function and behavioral novelty recognition through mechanisms independent of their trans-synaptic binding partners.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Cell type-specific pharmacology of NMDA receptors using masked MK801

    Yunlei Yang et al.
    The small molecule NMDA-receptor antagonist MK801 has been genetically targeted to specific cell types in brain tissue to examine the role of NMDA receptors in cocaine-induced synaptic plasticity.
    1. Neuroscience

    LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses

    Alessandra Sclip, Thomas C Südhof
    LAR-RPTPs are not essential for synapse formation, but they are important determinants of synapse properties as they contribute to regulate postsynaptic NMDA receptor function.
    1. Neuroscience

    A family of photoswitchable NMDA receptors

    Shai Berlin et al.
    Molecular engineering can generate light-sensitive NMDA receptors with specific subunit combinations.
    1. Neuroscience

    Ring finger protein 10 is a novel synaptonuclear messenger encoding activation of NMDA receptors in hippocampus

    Margarita C Dinamarca et al.
    A protein called RNF10 relays messages from synapses to neuron cell nuclei, and is responsible for long-lasting modifications of dendritic spines as observed after activation of synaptic glutamate receptors.
    1. Neuroscience

    An NMDA receptor-dependent mechanism for subcellular segregation of sensory inputs in the tadpole optic tectum

    Ali S Hamodi et al.
    An activity-dependent mechanism sculpts subcellular segregation of sensory inputs.
    1. Neuroscience

    Distinct roles of NMDA receptors at different stages of granule cell development in the adult brain

    Yangling Mu et al.
    NMDARs promote spine formation to control survival of adult-born granule cells, but gauge spine enlargement and recruitment of AMPARs in both developing and mature neurons.

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