122 results found
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    PUMILIO, but not RBMX, binding is required for regulation of genomic stability by noncoding RNA NORAD

    Mahmoud M Elguindy et al.
    Interaction with PUMILIO is essential for maintenance of genomic stability by the cytoplasmic long noncoding RNA NORAD, whereas binding to RBMX is dispensable for this function.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    PUMILIO hyperactivity drives premature aging of Norad-deficient mice

    Florian Kopp et al.
    Long noncoding RNA Norad performs an essential function in mammalian physiology by inhibiting the activity of PUMILIO RNA binding proteins, thereby suppressing a multi-system degenerative phenotype resembling premature aging.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Noncoding RNA: Aging well with Norad

    Filipa Carvalhal Marques, Igor Ulitsky
    In mice, deleting a long noncoding RNA drives premature aging.
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    1. Developmental Biology

    Cytoplasmic sharing through apical membrane remodeling

    Nora G Peterson et al.
    Apical membrane remodeling in a resorptive Drosophila epithelium generates a shared multinuclear cytoplasm.
    1. Microbiology and Infectious Disease

    Co-evolution within structured bacterial communities results in multiple expansion of CRISPR loci and enhanced immunity

    Nora C Pyenson, Luciano A Marraffini
    Cells must acquire multiple viral spacer sequences to neutralize mutant escaper phages and form colonies during the CRISPR-Cas immune response.
  1. Point of View: Nomad scientists and the ones left behind

    Maya Bar et al.
    To improve the diversity of the scientific workforce, we should not penalize researchers who are unable to move abroad for long periods.
    1. Microbiology and Infectious Disease

    Bacterial Immunity: An adaptable defense

    Michael A Schelling, Dipali G Sashital
    The response of bacteria to the threat posed by phages depends on their local environment.
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    1. Cell Biology

    Control of brown adipose tissue adaptation to nutrient stress by the activin receptor ALK7

    Patricia Marmol et al.
    The activin receptor ALK7 regulates the adaptation of brown adipose tissue to nutrient availability by preventing over-activation of signaling pathways induced by fasting, allowing appropriate response to cold exposure.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Dynamic enhancer partitioning instructs activation of a growth-related gene during exit from naïve pluripotency

    Maxim Greenberg et al.
    Three-dimensional chromatin architecture facilitates a promoter switch in order to ensure maintained expression of a gene involved in growth during embryonic stem cell differentiation.

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