Interaction with PUMILIO is essential for maintenance of genomic stability by the cytoplasmic long noncoding RNA NORAD, whereas binding to RBMX is dispensable for this function.
Long noncoding RNA Norad performs an essential function in mammalian physiology by inhibiting the activity of PUMILIO RNA binding proteins, thereby suppressing a multi-system degenerative phenotype resembling premature aging.
The visual message conveyed by retinal neurons to the brain when signaling natural scenes resembles the individual receptive fields only when viewed in context of the neuronal population.
The activin receptor ALK7 regulates the adaptation of brown adipose tissue to nutrient availability by preventing over-activation of signaling pathways induced by fasting, allowing appropriate response to cold exposure.