4,614 results found
    1. Cancer Biology
    2. Cell Biology

    A novel L1CAM isoform with angiogenic activity generated by NOVA2-mediated alternative splicing

    Francesca Angiolini et al.
    Endothelial cells express a soluble isoform of the L1CAM cell adhesion molecule that is generated by the splicing factor NOVA2 and induces angiogenesis, with relevant implications for ovarian cancer vascularization.
    1. Neuroscience

    NOVA2-mediated RNA regulation is required for axonal pathfinding during development

    Yuhki Saito et al.
    The RNA-binding protein NOVA2 coordinately regulates the alternative splicing of key components in axon guidance and outgrowth pathways, with severe functional consequences.
    1. Evolutionary Biology
    2. Genetics and Genomics

    A de novo evolved gene in the house mouse regulates female pregnancy cycles

    Chen Xie et al.
    A female specifically expressed new protein-coding gene that has emerged out of non-coding sequences without detectable signatures of adaptive evolution affects female pregnancy cycles.
    1. Medicine
    2. Neuroscience

    Two de novo GluN2B mutations affect multiple NMDAR-functions and instigate severe pediatric encephalopathy

    Shai Kellner et al.
    Two novel mutations in the GRIN2B gene reduce glutamate affinity by >1000-fold, reduce the receptors proton-sensitivity, and exert a dominant-negative effect over receptors in neurons.
    1. Genetics and Genomics

    Fast turnover of genome transcription across evolutionary time exposes entire non-coding DNA to de novo gene emergence

    Rafik Neme, Diethard Tautz
    Deep sequencing of transcriptomes from closely related taxa shows that the whole genome can become subject to evolutionary testing within a short time frame via de novo evolution of genes.
    1. Developmental Biology
    2. Neuroscience

    NOVA regulates Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord

    Janelle C Leggere et al.
    Alternative splicing of the Dcc gene, which is controlled by the NOVA RNA-binding proteins, is crucial during neuronal migration and axon guidance.
    1. Cell Biology
    2. Developmental Biology

    NOCA-1 functions with γ-tubulin and in parallel to Patronin to assemble non-centrosomal microtubule arrays in C. elegans

    Shaohe Wang et al.
    The C. elegans ninein homolog NOCA-1 is important for the assembly of non-centrosomal microtubule arrays required for embryo production, nuclear positioning and larval development.
    1. Structural Biology and Molecular Biophysics

    De novo design of a homo-trimeric amantadine-binding protein

    Jooyoung Park et al.
    The first successful de novo design of a homo-trimeric protein that binds a C3 symmetric small molecule larger than a metal ion is an advance for computational protein design.
    1. Genetics and Genomics

    Large, three-generation human families reveal post-zygotic mosaicism and variability in germline mutation accumulation

    Thomas A Sasani et al.
    Rates of germline mutation accumulation are highly variable across families of similar genetic ancestry, and post-zygotic mosaicism is a substantial source of de novo mutations.
    1. Neuroscience

    Precisely timed dopamine signals establish distinct kinematic representations of skilled movements

    Alexandra Bova et al.
    Dopamine signaling gradually causes long-lasting changes in fine motor coordination that can later be activated by acute changes in dopamine neuron activity.

Refine your results by:

Type
Research categories