1,616 results found
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses

    Simon Langer et al.
    By inhibiting the activation of NF-κB, HIV-1 Vpu exerts much broader immunosuppressive effects than previously anticipated and may be an important determinant of chronic inflammation in HIV-1 infected individuals.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence

    Michael J Steinbaugh et al.
    Germ cell ablation delays C. elegans aging, in part, because unconsumed fat triggers activation of the detoxification factor SKN-1/Nrf, which is regulated by lipid signals and maintains lipid homeostasis.
    1. Cell Biology

    YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-κB

    Gisela Schimmack et al.
    The deubiquitinating enzyme YOD1 binds to the E3 ligase TRAF6 to counteract p62/sequestosome1 mediated pro-inflammatory NF-κB signaling in response to interleukin-1.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Transgenerational inheritance of ethanol preference is caused by maternal NPF repression

    Julianna Bozler et al.
    Maternally experienced environmental stress leads to multigenerational inheritance of ethanol preference and an altered rewards pathway in Drosophila melanogaster.
    1. Cell Biology
    2. Neuroscience

    Multiple factors maintain assembled trans-SNARE complexes in the presence of NSF and αSNAP

    Eric A Prinslow et al.
    Biophysical analyses indicate that Munc18-1, Munc13-1, synaptotagmin-1 and complexin-1 maintain assembled trans-SNARE complexes in the presence of NSF-alphaSNAP, suggesting that they form part of the primed state of synaptic vesicles.
    1. Microbiology and Infectious Disease

    NSF-mediated disassembly of on- and off-pathway SNARE complexes and inhibition by complexin

    Ucheor B Choi et al.
    NSF is part of a membrane trafficking quality control system that disassembles both properly formed and off-pathway SNARE complexes, and the disassembly activity may be regulated by complexin.
    1. Structural Biology and Molecular Biophysics

    How HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4

    Xuefeng Ren et al.
    The structure of the Nef:AP-2 complex has been determined and used as the basis of a model that explains how HIV-1 Nef downregulates the CD4 receptor from the surface of the infected cells.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Structural principles of SNARE complex recognition by the AAA+ protein NSF

    K Ian White et al.
    Electron-cryomicroscopy structures of the supercomplex of NSF, αSNAP, and neuronal SNAREs in the presence of ATP under non-hydrolyzing conditions at 3.9 Å resolution reveal interactions between the N-terminal residues of SNAP-25 and NSF.
    1. Neuroscience

    Multivesicular bodies mediate long-range retrograde NGF-TrkA signaling

    Mengchen Ye et al.
    Multivesicular bodies deliver long-range retrograde nerve growth factor (NGF) signals and serve as essential signaling and sorting platforms in the cell soma, and multivesicular body (MVB) cargoes dictate their vesicular fate.

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