B-type natriuretic peptide (BNP) modulates itch via BNP-NPRC pathway by enhancing NMB-NMBR signaling, which is independently of gastrin-releasing peptide (GRP)-GRPR signaling in the spinal cord.

A combination of morpholino-based knockdowns, pharmacological inhibitors, and rescue assays reveal a novel role for natriuretic peptide signaling in the regulation of cell fates in the embryonic ectoderm.

Fibroblast growth factor induces dephosphorylation and inactivation of the NPR2 guanylyl cyclase, thus decreasing cyclic GMP production in growth plate chondrocytes and contributing to FGF-dependent decreases in bone growth.

Expression of plant immune genes is controlled by the opposing actions of ubiquitin ligases and deubiquitinases that modify the master coactivator NPR1, thereby regulating its intrinsic transcriptional activity.

Molecular and genetics approaches reveal a dual regulatory role of neuronal G-protein-coupled receptor NPR-15 in both immunity and avoidance behavior, independent of aerotaxis, mediated by amphid sensory neurons, ASJ.

The transfer RNA thiolation modification is required for the efficient translation of the master immune regulator NPR1 in plants.

Photodamaged chloroplasts are targeted for vacuolar degradation through microautophagy by the NBR1 autophagy receptor without the participation of the canonical autophagy machinery.

NPC1 is a genetic determinant of filovirus susceptibility in bats, and some variations in bat NPC1 may reflect host adaptations to reduce filovirus replication and virulence.

A lipid acts to promote the development of nematode worm larvae through activation of an enzyme complex called TORC1.

The N-terminal domain of one NPC1 molecule can transfer its cholesterol to another NPC1 molecule lacking the N-terminal domain, suggesting that NPC1 forms multimers that transport cholesterol out of lysosomes.