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    1. Ecology
    2. Evolutionary Biology
    House sparrow illustration

    The Natural History of Model Organisms: The house sparrow in the service of basic and applied biology

    Haley E Hanson, Noreen S Mathews ... Lynn B Martin
    The house sparrow, one of the most ubiquitous birds in the world, is now used extensively in studies across disciplines in the life sciences.
    1. Neuroscience

    Cortical adaptation to sound reverberation

    Aleksandar Z Ivanov, Andrew J King ... Nicol S Harper
    The auditory system adapts to the changing acoustics of reverberant environments by temporally shifting the inhibitory tuning of cortical neurons to reduce the effects of reverberation.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Nicotinic acetylcholine receptor signaling maintains epithelial barrier integrity

    Nadja S Katheder, Kristen C Browder ... Heinrich Jasper
    Signaling through nicotinic acetylcholine receptors in enterocytes impacts barrier integrity in the Drosophila intestine by regulating formation of the peritrophic matrix.
    1. Structural Biology and Molecular Biophysics

    Allosteric signalling in the outer membrane translocation domain of PapC usher

    Irene Farabella, Thieng Pham ... Maya Topf
    Input from computational models has enabled the detection of allosteric communication that modulates the gating mechanism of a bacterial outer-membrane protein.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Ligand modulation of sidechain dynamics in a wild-type human GPCR

    Lindsay D Clark, Igor Dikiy ... Daniel M Rosenbaum
    Generation of a highly deuterated 13C-methyl labeled wild-type GPCR sample is used to facilitate characterization of the molecular environments and fast ps-ns dynamics of sidechains when the receptor is bound to ligands of different efficacy.
    1. Cell Biology

    The ULK1-FBXW5-SEC23B nexus controls autophagy

    Yeon-Tae Jeong, Daniele Simoneschi ... Michele Pagano
    The control of SEC23B degradation by SCFFBXW5 and ULK1 regulates the autophagy.
    1. Neuroscience

    Hierarchical temporal prediction captures motion processing along the visual pathway

    Yosef Singer, Luke Taylor ... Nicol S Harper
    Neural network modeling shows that hierarchical application of the simple computational principle of predicting future sensory input from its past can capture features of visual motion processing from the retina to the visual cortex.
    1. Ecology

    Little evidence that Eurasian jays protect their caches by responding to cues about a conspecific’s desire and visual perspective

    Piero Amodio, Benjamin G Farrar ... Nicola S Clayton
    Across five experiments, Eurasian jays’ caching behaviour provides little evidence of the ability to integrate cues about a potential pilferer’s visual perspective and desire and, challenging previous findings, to respond to either of the two social cues independently.
    1. Medicine

    Inflammatory osteolysis is regulated by site-specific ISGylation of the scaffold protein NEMO

    Naga Suresh Adapala, Gaurav Swarnkar ... Yousef Abu-Amer
    Site-specific modification of NEMO facilitates RANKL signal specificity in myeloid progenitors and serves as a potential target to modulate inflammatory osteolysis through ISG15-dependent autophagy.
    1. Neuroscience

    Empathic pain evoked by sensory and emotional-communicative cues share common and process-specific neural representations

    Feng Zhou, Jialin Li ... Benjamin Becker
    Machine learning analyses reveal that the observation of acute pain inflictions and facial expressions of pain evoke shared pain-specific neural representations.