79 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Mitochondria supply ATP to the ER through a mechanism antagonized by cytosolic Ca2+

    Jing Yong, Helmut Bischof ... Randal J Kaufman
    ATP enters the endoplasmic reticulum (ER) lumen through an SLC35B1/AXER-dependentCaATiER mechanism, and ATP usage in the ER renders 'anti-Warburg' effect by increasing ATP regeneration from OxPhos while decreasing glycolysis.
    1. Cell Biology
    2. Neuroscience

    Activation of the CaMKII-Sarm1-ASK1-p38 MAP kinase pathway protects against axon degeneration caused by loss of mitochondria

    Chen Ding, Youjun Wu ... Marc Hammarlund
    Axon degeneration due to loss of mitochondria is suppressed by CaMKII activity and MAP kinase signaling.
    1. Cell Biology

    Ezrin defines TSC complex activation at endosomal compartments through EGFR-AKT signaling

    Giuliana Giamundo, Daniela Intartaglia ... Ivan Conte
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Structural Biology and Molecular Biophysics

    Structure-based analysis of CysZ-mediated cellular uptake of sulfate

    Zahra Assur Sanghai, Qun Liu ... Filippo Mancia
    Structures of CysZ show a antiparallel membrane protein with an unanticipated fold and together with functional characterization provide insight into a bacterial sulfate translocating system.
    1. Developmental Biology
    2. Neuroscience

    Synaptic mitochondria regulate hair-cell synapse size and function

    Hiu-tung C Wong, Qiuxiang Zhang ... Katie Kindt
    Mitochondrial calcium influx plays distinct roles in presynapse formation, function and stability in sensory hair cells.
    1. Cell Biology

    Mitochondrial flashes regulate ATP homeostasis in the heart

    Xianhua Wang, Xing Zhang ... Heping Cheng
    Mitochondrial flashes counteract the imbalance of ATP supply-and-demand and constitute an auto-regulator of ATP homeostasis in the heart.
    1. Neuroscience

    Circadian regulation of endoplasmic reticulum calcium response in cultured mouse astrocytes

    Ji Eun Ryu, Kyu-Won Shim ... Eun Young Kim
    Astrocytic ER calcium release and gap junction communication exhibit circadian modulation driven by HERPUD1, highlighting the importance of astrocytic circadian rhythms in brain function.
    1. Neuroscience

    Cestode larvae excite host neuronal circuits via glutamatergic signaling

    Anja de Lange, Hayley Tomes ... Joseph V Raimondo
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Cell Biology
    2. Plant Biology

    A receptor-like kinase mutant with absent endodermal diffusion barrier displays selective nutrient homeostasis defects

    Alexandre Pfister, Marie Barberon ... Niko Geldner
    The SCHENGEN3 protein is needed for the progression of isolated microdomains into a continuous band, which is necessary for the establishment of the major extracellular diffusion barrier in plant roots: the Casparian strip.
    1. Ecology

    Engineering multifunctional rhizosphere probiotics using consortia of Bacillus amyloliquefaciens transposon insertion mutants

    Jingxuan Li, Chunlan Yang ... Zhong Wei
    Increasing the intra-species phenotypic diversity of a plant-beneficial bacterium effectively improves probiotic consortium functioning and plant growth promotion in agricultural systems.

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