In humans, specific sequence features can predict whether meiotic recombination occurs at sites bound by the protein PRDM9, whose DNA-binding zinc-finger domain can unexpectedly bind to gene promoters and to other copies of PRDM9.
Transcriptional regulation evolves at indistinguishable rates in mammals, birds and insect lineages despite large differences in underlying rates of sequence evolution.
High resolution in vivo imaging of the zebrafish heart morphogenesis allows quantitative testing of the impact of stretch sensitive channels during outflow tract valve development.
Matthew G Marzo, Jacqueline M Griswold ... Steven M Markus
A mutagenesis screen in budding yeast sheds light on dynein regulation and function, and reveals the molecular basis for disease in patients suffering from neuropathies caused by dynein dysfunction.
A screen of lactic acid bacteria reveals that diet modulates the age-dependent decline of thermotaxis behavior in C. elegans without changing the organismal lifespan.
A combination of animal models reveal how the molecular mechanisms of exosome secretion (RalA/B-dependent) are linked to their cargo content and their function in breast cancer pre-metastatic niche formation.
The polo-like kinase (Plk1) phophorylates the C. elegans lamin LMN-1 to promote timely lamina disassembly, which is essential for the merging of the parental chromosomes at the beginning of life.
Clair R Henthorn, Paul M Airs ... Mostafa Zamanian
A single-cell gene expression atlas in a human parasitic nematode provides new insights into the distribution of anthelmintic targets and the origins of secretory molecules with diagnostic and therapeutic potential at the host–parasite interface.
Time-lapse imaging and the modular recreation of host physiology reveal that alveolar epithelial cells, potential permissive infection sites for Mycobacterium tuberculosis, can restrict early bacterial growth via surfactant secretion.
