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    1. Cell Biology
    2. Physics of Living Systems

    A mechano-osmotic feedback couples cell volume to the rate of cell deformation

    Larisa Venkova, Amit Singh Vishen ... Matthieu Piel
    Whether deforming cells behave as elastic balls (deforming at constant volume) or as sponges (loosing volume as they deform) depends on how fast they change their shape, because the cell volume depends on the tension of the plasma membrane.
    1. Neuroscience

    The distinct roles of calcium in rapid control of neuronal glycolysis and the tricarboxylic acid cycle

    Carlos Manlio Díaz-García, Dylan J Meyer ... Gary Yellen
    When neurons are stimulated, calcium entry into mitochondria upregulates mitochondrial energy production, but glycolytic energy production in the cytosol is stimulated by elevated energy demand, not Ca2+ signaling.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Exploring the K+ binding site and its coupling to transport in the neurotransmitter:sodium symporter LeuT

    Solveig G Schmidt, Andreas Nygaard ... Claus J Loland
    Potassium presumably binds to the Na1 site in LeuT, playing a role in inwardly rectifying the transport of substrates.
    1. Computational and Systems Biology
    2. Developmental Biology

    Size control of the inner ear via hydraulic feedback

    Kishore R Mosaliganti, Ian A Swinburne ... Sean G Megason
    Size regulation of the otic vesicle, the progenitor of the inner ear, is mediated by mechanical feedback involving fluid influx, hydraulic pressure, and tissue mechanics.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Proton-transporting heliorhodopsins from marine giant viruses

    Shoko Hososhima, Ritsu Mizutori ... Hideki Kandori
    A viral heliorhodopsin from Emiliania huxleyi virus 202 (V2HeR3) is a light-activated proton transporter, which has the potential to depolarize the host cells by light, possibly to overcome the host defense mechanisms or to prevent superinfection.
    1. Structural Biology and Molecular Biophysics

    Structural insights into sodium transport by the oxaloacetate decarboxylase sodium pump

    Xin Xu, Huigang Shi ... Song Xiang
    The structure of the membrane-integrated components of a unique substrate decarboxylation-driven primary-active sodium pump provides insights into its transport mechanism.
    1. Cell Biology
    2. Computational and Systems Biology

    Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block

    Jakub Tomek, Alfonso Bueno-Orovio ... Blanca Rodriguez
    A computer model of human cardiomyocyte was produced and validated on independent datasets, overcoming shortcomings of its predecessors, also yielding broadly relevant insights and results on major ionic currents.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Ionic selectivity and thermal adaptations within the voltage-gated sodium channel family of alkaliphilic Bacillus

    Paul G DeCaen, Yuka Takahashi ... David E Clapham
    Not all members of the bacteria sodium channel family are sodium channels - those found in Bacillus are highly adaptable and can be converted into many selectivity types.
    1. Cell Biology

    Testing the ion-current model for flagellar length sensing and IFT regulation

    Hiroaki Ishikawa, Jeremy Moore ... Wallace F Marshall
    A model for flagellar length control based on calcium influx is rejected based on quantitative measurements in Chlamydomonas cells.