131 results found
    1. Neuroscience

    Vasoactive intestinal peptide-expressing interneurons are impaired in a mouse model of Dravet syndrome

    Kevin M Goff, Ethan M Goldberg
    Vasoactive intestinal peptide-expressing GABAergic interneurons in cerebral cortex express the sodium channel subunit Nav1.1, and a defined subset of VIP interneurons are dysfunctional in a mouse model of Dravet syndrome.
    1. Structural Biology and Molecular Biophysics

    Polyunsaturated fatty acid analogues differentially affect cardiac NaV, CaV, and KV channels through unique mechanisms

    Briana M Bohannon et al.
    Polyunsaturated fatty acid analogues show selectivity for different cardiac ion channels, suggesting their potential use for the treatment of different subtypes of Long QT Syndrome.
    1. Neuroscience

    Voltage-gated Na+ currents in human dorsal root ganglion neurons

    Xiulin Zhang et al.
    Human sensory neurons may not only bridge a critical gap between drug discovery and clinical trials, but force a re-evaluation of basic assumptions about the mechanisms controlling primary afferent excitability.
    1. Neuroscience

    Novel charged sodium and calcium channel inhibitor active against neurogenic inflammation

    Seungkyu Lee et al.
    A cationic molecule derived from an uncharged Cav2.2 calcium channel inhibitor powerfully inhibits both sodium and calcium channels with extracellular application and inhibits both pain and neurogenic inflammation.
    1. Cell Biology

    KChIP2 is a core transcriptional regulator of cardiac excitability

    Drew M Nassal et al.
    The ion channel accessory subunit KChIP2 has a transcriptional role that provides regulation over miRNA targets, driving the adverse remodeling of key ion channels during cardiac stress and leading to the development of arrhythmia.
    1. Medicine
    2. Neuroscience

    Aberrant subchondral osteoblastic metabolism modifies NaV1.8 for osteoarthritis

    Jianxi Zhu et al.
    Osteoblastic PGE2 induces pain and OA progression by NaV1.8 modification and serves as a potential target multiple skeletal pain and degenerations.
    1. Neuroscience

    A deleterious Nav1.1 mutation selectively impairs telencephalic inhibitory neurons derived from Dravet Syndrome patients

    Yishan Sun et al.
    A human cellular model of a prototypical form of intractable childhood epilepsy supports selective impairment of inhibitory neurons as a key pathophysiological mechanism.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Ca2+ entry into neurons is facilitated by cooperative gating of clustered CaV1.3 channels

    Claudia M Moreno et al.
    CaV1.3 channels of the short isoform are coupled via their C-terminal domains in a Ca2+-CaM-dependent manner, which facilitates Ca2+ influx and increases the discharge of hippocampal neurons.
    1. Neuroscience

    Computation identifies structural features that govern neuronal firing properties in slowly adapting touch receptors

    Daine R Lesniak et al.
    Computer simulations show that the firing patterns of branched touch receptors can be set in part by the organization of their sensory endings in the skin.
    1. Neuroscience

    Neuropathic Pain: The pros and cons of degeneracy

    Jean-Marc Goaillard, Martial A Dufour
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