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    1. Cell Biology

    Transcriptomic analyses reveal rhythmic and CLOCK-driven pathways in human skeletal muscle

    Laurent Perrin et al.
    Rhythmic transcriptome analyses of human skeletal muscle tissue and cultured primary myotubes reveal an essential role for the circadian coordination of glucose homeostasis and lipid metabolism in human skeletal muscle.
    1. Cancer Biology
    2. Neuroscience

    Pharmacological augmentation of nicotinamide phosphoribosyltransferase (NAMPT) protects against paclitaxel-induced peripheral neuropathy

    Peter M LoCoco et al.
    Stimulation of the rate-limiting enzyme in the NAD salvage pathway protected against neurotoxicity and subsequent peripheral neuropathy associated with the widely utilized anticancer drug, paclitaxel.
    1. Neuroscience

    mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice

    Luke K Burke et al.
    AGRP neurons integrate environmental food-related cues with internal metabolic signals to modulate interscapular brown adipose tissue thermogenesis and energy expenditure, at least in part, via mTORC1 signalling.
    1. Neuroscience

    NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion

    Yo Sasaki et al.
    Axonal metabolic flux analysis demonstrates that expression of NMNAT1 blocks axonal degeneration in cultured mouse neurons not by altering NAD+ synthesis, but rather by inhibiting injury-induced, SARM1-dependent NAD+ consumption.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    MicroRNAs shape circadian hepatic gene expression on a transcriptome-wide scale

    Ngoc-Hien Du et al.
    In the liver, microRNAs exert widespread functions in the modulation of phases and amplitudes of clock-controlled gene expression, but their influence on the core clock is remarkably mild.