15 results found
    1. Immunology and Inflammation

    MicroRNA-122 supports robust innate immunity in hepatocytes by targeting the RTKs/STAT3 signaling pathway

    Hui Xu et al.
    The liver-specific miRNA microRNA-122 plays a previously unknown role in hepatocyte intrinsic innate immunity by targeting the RTKs/STAT3 signaling pathway.
    1. Chromosomes and Gene Expression

    Dual control of NAD+ synthesis by purine metabolites in yeast

    Benoît Pinson et al.
    Two distinct processes drive coordinated synthesis of purine and pyridine (NAD+) nucleotides in response to AICAR derivatives and ATP.
    1. Developmental Biology
    2. Neuroscience

    Sox1a mediates the ability of the parapineal to impart habenular left-right asymmetry

    Ingrid Lekk et al.
    The sox1a gene is required for a small group on neurons on the left side of the brain to influence the generation and left-sided character of their future synaptic partners.
    1. Cell Biology

    Nicotinamide adenine dinucleotide is transported into mammalian mitochondria

    Antonio Davila et al.
    Stable isotope labeling reveals that NAD crosses the inner membrane of mammalian mitochondria via an unknown transporter.
    1. Neuroscience

    mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice

    Luke K Burke et al.
    AGRP neurons integrate environmental food-related cues with internal metabolic signals to modulate interscapular brown adipose tissue thermogenesis and energy expenditure, at least in part, via mTORC1 signalling.
    1. Neuroscience

    Recurrent circuit dynamics underlie persistent activity in the macaque frontoparietal network

    Eric Hart, Alexander C Huk
    Simultaneous recordings of neural ensembles in both the frontal and parietal cortices reveal how persistent activity can be maintained in the primate brain during visuospatial working memory.
    1. Biochemistry and Chemical Biology

    Semisynthetic biosensors for mapping cellular concentrations of nicotinamide adenine dinucleotides

    Olivier Sallin et al.
    A family of fluorescent biosensors for nicotinamide adenine dinucleotides allows quantification of these cofactors in live cells with spatio-temporal resolution.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Context-enriched interactome powered by proteomics helps the identification of novel regulators of macrophage activation

    Arda Halu et al.
    Enriching the interactome with context-specific information from proteomics helps the identification of novel regulators of macrophage activation.
    1. Epidemiology and Global Health

    Discovery proteomics in aging human skeletal muscle finds change in spliceosome, immunity, proteostasis and mitochondria

    Ceereena Ubaida-Mohien et al.
    The changes in the skeletal muscle proteome with age indicate the roots of the decline in muscle function with age.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    MicroRNAs shape circadian hepatic gene expression on a transcriptome-wide scale

    Ngoc-Hien Du et al.
    In the liver, microRNAs exert widespread functions in the modulation of phases and amplitudes of clock-controlled gene expression, but their influence on the core clock is remarkably mild.

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