16 results found
    1. Structural Biology and Molecular Biophysics

    Structure and dynamics of a nanodisc by integrating NMR, SAXS and SANS experiments with molecular dynamics simulations

    Tone Bengtsen et al.
    Molecular simulations, small-angle X-ray and neutron scattering experiments and previously measured NMR experiments were combined to study the structure and dynamics of the proteins and lipids in a nanodisc.
    1. Cell Biology
    2. Developmental Biology

    Nanos promotes epigenetic reprograming of the germline by down-regulation of the THAP transcription factor LIN-15B

    Chih-Yung Sean Lee et al.
    Nanos is required for germline specification by erasure of maternal program in primordial germ cells.
    1. Plant Biology

    Antimicrobial peptide expression in a wild tobacco plant reveals the limits of host-microbe-manipulations in the field

    Arne Weinhold et al.
    The attempt to manipulate a microbiome in planta to study the ecological consequences under field conditions leaves plants and their microbes surprisingly unimpressed.
    1. Chromosomes and Gene Expression

    Aurora-A mediated histone H3 phosphorylation of threonine 118 controls condensin I and cohesin occupancy in mitosis

    Candice L Wike et al.
    A histone modification that alters the nucleosome structure occurs in mitosis and promotes chromosome packaging and the timely removal of condensin I and cohesion, to achieve chromosome segregation.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Resistome diversity in cattle and the environment decreases during beef production

    Noelle R Noyes et al.
    Interventions in feedlots and abattoirs place selective pressure on the beef cattle resistome, which differentially impacts the public health risk of antimicrobial resistance from beef production sources.
    1. Neuroscience

    Cell type specificity of neurovascular coupling in cerebral cortex

    Hana Uhlirova et al.
    Excitatory and inhibitory cortical neurons drive parallel vasodilatory pathways, while vasoconstriction is mediated exclusively by inhibition acting via Neuropeptide Y binding to Y1 receptors.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Toxoplasma gondii peptide ligands open the gate of the HLA class I binding groove

    Curtis McMurtrey et al.
    T. gondii infection alters how peptide ligands are presented to the immune system by inducing a previously unreported structural change in Human Leukocyte Antigens (HLAs).
    1. Structural Biology and Molecular Biophysics

    Ligand discrimination and gating in cyclic nucleotide-gated ion channels from apo and partial agonist-bound cryo-EM structures

    Jan Rheinberger et al.
    High resolution SthK channel cryo-EM structures in different ligand-bound states combined with single-channel functional data in the same conditions constrain a gating mechanism for CNG channels.
    1. Microbiology and Infectious Disease

    Cohabiting family members share microbiota with one another and with their dogs

    Se Jin Song et al.
    Research on humans and dogs reveals that the communities of microorganisms found on the skin, on the tongue and in the intestine are affected differently by age and cohabitation.
    1. Neuroscience

    Extracellular space preservation aids the connectomic analysis of neural circuits

    Marta Pallotto et al.
    Automated segmentation of neurons and identification of synapses in electron micrographs is significantly improved by using simple modifications to chemical fixation protocols that preserve extracellular space in the brain.

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