80 results found
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    FGF21 trafficking in intact human cells revealed by cryo-electron tomography with gold nanoparticles

    Maia Azubel et al.
    Specific attachment of molecularly defined gold nanoparticles enables precise localization, critical for structural studies in vivo, of proteins of unknown structure within the cellular milieu by cryo-electron tomography.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Optimization-by-design of hepatotropic lipid nanoparticles targeting the sodium-taurocholate cotransporting polypeptide

    Dominik Witzigmann et al.
    The combination of in vitro investigations, the zebrafish screening model and rodent experiments offered a unique approach to optimizing nanoparticles modified with Hepatitis B virus-derived peptides to specifically target hepatocytes.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The Peptidisc, a simple method for stabilizing membrane proteins in detergent-free solution

    Michael Luke Carlson et al.
    A simple, yet elegant method for robust self-assembly of diverse membrane proteins into soluble peptide nanoparticles for their structural and functional analysis in detergent-free solutions.
    1. Cancer Biology
    2. Human Biology and Medicine

    A hyperspectral method to assay the microphysiological fates of nanomaterials in histological samples

    Elliott D SoRelle et al.
    A new technique for biodistribution and targeted uptake studies of nanoparticle imaging agents is demonstrated and used to achieve levels of detail that are inaccessible through existing methods.
    1. Neuroscience

    Plasmon resonance and the imaging of metal-impregnated neurons with the laser scanning confocal microscope

    Karen J Thompson et al.
    A new method allows silver- and gold-labeled tissues to be imaged with confocal microscopy, avoiding the problem of fluorescence photobleaching.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Near-infrared photoactivatable control of Ca2+ signaling and optogenetic immunomodulation

    Lian He et al.
    A near-infrared light-stimulable optogenetic platform enables remote and wireless manipulation of calcium signaling and immune responses both in vitro and in vivo to achieve tailored function.
    1. Human Biology and Medicine
    2. Immunology and Inflammation

    Nanoparticulate carbon black in cigarette smoke induces DNA cleavage and Th17-mediated emphysema

    Ran You et al.
    The accumulation of carbon black nanoparticles in smokers' lungs causes sterile inflammation, double-strand DNA breaks and emphysema.
    1. Neuroscience

    Subcellular analysis of pigeon hair cells implicates vesicular trafficking in cuticulosome formation and maintenance

    Simon Nimpf et al.
    Cuticulosomes are organelles found in the hair cells of birds that are composed of ferritin nanoparticles, form rapidly after hatching by the fusion of vesicular structures, and may play an indirect role in magnetic sensation.
    1. Human Biology and Medicine
    2. Immunology and Inflammation

    Lung Disease: The soot of all evil

    Derek W Russell, J Edwin Blalock
    Insight
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    1. Physics of Living Systems
    2. Neuroscience

    Magnetogenetics: Problems on the back of an envelope

    Polina Anikeeva, Alan Jasanoff
    Insight
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