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    1. Cell Biology

    Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1

    Ling Luo et al.
    The eye produces a protein that inhibits the growth of blood vessels in the deep retina, which includes the photoreceptor layer, and disruption of this process can lead to blindness.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    The major β-catenin/E-cadherin junctional binding site is a primary molecular mechano-transductor of differentiation in vivo

    Jens-Christian Röper et al.
    The primary molecular mechanosensor involved in a physiological process of mechanically induced cell fate differentiation is revealed here for the first time in vivo, highly sensitive and potentially shared by all metazoan epithelia.
    1. Neuroscience

    Possible magneto-mechanical and magneto-thermal mechanisms of ion channel activation in magnetogenetics

    Mladen Barbic
    Several new magneto-mechanical and magneto-thermal mechanisms of ion channel activation in magnetogenetics are proposed that may explain some of the mysteries that challenge current understanding of the magnetogenetics experiments.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Gene activation by a CRISPR-assisted trans enhancer

    Xinhui Xu et al.
    Both exogenous and endogenous genes can be highly activated in cells by a new dCas9-based activator, CRISPR-assisted trans enhancer, that can be used to activate genes for biomedical applications.
    1. Physics of Living Systems

    Upper bound on the biological effects of 50/60 Hz magnetic fields mediated by radical pairs

    PJ Hore
    Any effects of environmental 50/60 Hz magnetic fields on human biology due to a radical pair mechanism should be no more dangerous than those incurred by travelling a few kilometres.
    1. Cell Biology

    Genome-wide interrogation of extracellular vesicle biology using barcoded miRNAs

    Albert Lu et al.
    A screen using artificially barcoded, exosomal microRNAs, paired with CRISPR guide RNAs, helped identify new players in multivesicular endosome exocytosis and a role for Wnt signaling.
    1. Cell Biology

    Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/γ-secretase at the cell surface

    Abril Angélica Escamilla-Ayala et al.
    Super-resolution microscopy sets a new strategy to comprehend the membrane organization of γ-secretase at single complex resolution identifying nanodomain associations and its diffusion in situ in the living membrane.
    1. Computational and Systems Biology

    A molecular view on the escape of lipoplexed DNA from the endosome

    Bart MH Bruininks et al.
    The molecular insight in lipoplex transfection mechanisms helps in the development of efficient and affordable gene delivery systems.
    1. Ecology

    Substantial near-infrared radiation-driven photosynthesis of chlorophyll f-containing cyanobacteria in a natural habitat

    Michael Kühl et al.
    Cyanobacteria with chlorophyll f show substantial near-infrared radiation-driven photosynthesis and can play an important role for primary production in endolithic, intertidal habitats.
    1. Neuroscience

    MagC, magnetic collection of ultrathin sections for volumetric correlative light and electron microscopy

    Thomas Templier
    The augmentation of resin-embedded sample blocks with magnetic resin allows remote actuation of ultrathin sections and deposition at high packing density onto silicon wafers for correlative light and electron microscopy.